Naslov
Indium-111-DTPA-octreoide scintigraphy in patients with carcinoid tumor

Autori
Težak, Stanko ; Ostojić, Rajko ; Perković, Zdravko ; Rustemović, Nadan ; Car, Nikica ; Papa, Branko ; Poropat, Mirjana ; Dodig, Damir ;

Izvornik
Radiology and Oncology (1318-2099) 33 (1999), 4; 283-290

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
carcinoid tumor-radionuclide imaging; indium radiosotopes; octreoide; DTPA; 111In-octreotide scintigraphy; diagnosis; nonspecific bowel accumulation

Sažetak
The aim of the study was the evaluation of clinical utility an comparsion of 111In-DTPA-octreotide receptor scintigraphy (SRS) wit conventional imaging modalities (CIM) in the detection of carcinoid tumor. Patients and Methods: 14 patients with pathohistologically proven diagnosis of carcinioid tumor and one patient with clinical suspicion of carcaniod tumor were investigated by SRS. SRS was performed for localization of primary tumor, recurrence or estimation of spread of the disease after CIM had been complated. Whole body scans and single photon emission computed tomography SPECT) were acquired 6 and 24 h after the application of radiopharmaceutical. The intesity of non specific radiopharmaceutical uptake in the bowel was assessed semiquantitatively by score using whole body scans. Results: The evaluation was done for patients and for tumor sites. The sensitivity, specifity, and positive and negative predictive values for patient evaluation were 89 per cent, 100 per cent, and 80 per cent, respectively for both CIM and SRS, whereas for tumor sites, these parametres were 69 per cent, 100 per cent, 100 per cent, and 82 per cent for CIM, and 88 per cent, 100 per cent, 100 per cent, and 92 per cent for SRS. Intensity score of nonspecific 111In-octreotide bowel accumulation was 0.92 and 2.01 for 6 and 24 h scans respectively (p less then 0.01). Conclusion: 111In –octreotide scintigraphy should be included in the diagnostic algorithm for the patients with clinical suspicion of carcinoid for the assessment of patients with proven carcinoid tumor.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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