Naslov
Alkaline phosphatase is independently associated with renal function in normoalbuminuric type 1 diabetic patients

Autori
Bulum, Tomislav ; Blaslov, Kristina ; Zibar, Karin ; Duvnjak, Lea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Diabetologia 2013 ; 56 (Suppl. 1): S476-S477 / - , 2013

Skup
49th EASD Annual Meeting

Mjesto i datum
Barcelona, Španjolska, 23.09.2013. - 27.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
type 1 diabetes; renal function; nonalcoholic fatty liver disease

Sažetak
Nonalcoholic fatty liver disease (NAFLD) is associated with an increased prevalence of chronic kidney disease. The aim of this study was to explore the relationship between markers of NAFLD and renal function in normoalbuminuric type 1 diabetic patients. This study included 313 normoalbuminuric type 1 diabetic patients with estimated glomerular filtration rate (eGFR) > 60 mlmin-11.73m-2, without clinical evidence of cirrhosis or other causes of chronic liver disease and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. ALT, GGT, bilirubin and ferritin levels were significantly higher in subjects in the highest quartile of serum creatinine compared to those in lowest quartile (21 vs 20 U/L, 18 vs 14 U/L, 14 vs 10 µmol/L, and 103 vs 25 µg/L, respectively, for all p<0.05). ALK levels were significantly higher in subjects in the highest quartile of urinary albumin excretion rate compared to those in lowest quartile (71 vs 69 U/L, p=0.03), as well as in hyperfiltrating subjects compared to those with normal or mildly impaired eGFR (81 vs 68 and 64 U/L, p<0.001). In a multiple logistic regression model only ALK levels were significantly associated with disturbances in serum creatinine and eGFR in our subjects (p≤0.007), with odds ratios of 0.98 to 1.02. This study, conducted in normoalbuminuric type 1 diabetic patients with normal or mildly impaired renal function and with no therapeutic intervention, suggest that ALK may play a role in the pathogenesis of renal impairment in type 1 diabetic patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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