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Pregled bibliografske jedinice broj: 643180

Prolonged exposure to benzodiazepines and alcohol: Adaptive changes of GABA-A receptors associated with development of tolerance and dependence

Švob Štrac, Dubravka
Prolonged exposure to benzodiazepines and alcohol: Adaptive changes of GABA-A receptors associated with development of tolerance and dependence // COST Action CM1103 Training School “Structure- based drug design for diagnosis and treatment of neurological diseases”
Istanbul, Turska, 2013. (predavanje, nije recenziran, neobjavljeni rad, znanstveni)

CROSBI ID: 643180 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Prolonged exposure to benzodiazepines and alcohol: Adaptive changes of GABA-A receptors associated with development of tolerance and dependence

Autori
Švob Štrac, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
COST Action CM1103 Training School “Structure- based drug design for diagnosis and treatment of neurological diseases”

Mjesto i datum
Istanbul, Turska, 09.09.2013. - 13.09.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
benzodiazepines; alcohol; GABA-A receptors; tolerance and dependence

Sažetak
Prolonged exposure to benzodiazepines and alcohol, substances known to produce tolerance and dependence and also to be abused, leads to adaptive changes in GABA-A receptors. To further explore the mechanisms responsible for these phenomena, we studied the effects of prolonged benzodiazepine and alcohol treatment on the recombinant α1β2γ2S GABA-A receptors, stably expressed in human embryonic kidney (HEK) 293 cells. The results suggest that long-term alcohol exposure induces changes of recombinant GABA-A receptors similar to chronic benzodiazepines. Moreover our findings support the involvement of functional uncoupling of receptor binding sites in the development of tolerance and dependence.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0000000-2448 - Stres, GABA-A receptori i mehanizmi djelovanja neuropsihofarmaka (Švob Štrac, Dubravka, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Dubravka Švob Štrac (autor)

Citiraj ovu publikaciju:

Švob Štrac, Dubravka
Prolonged exposure to benzodiazepines and alcohol: Adaptive changes of GABA-A receptors associated with development of tolerance and dependence // COST Action CM1103 Training School “Structure- based drug design for diagnosis and treatment of neurological diseases”
Istanbul, Turska, 2013. (predavanje, nije recenziran, neobjavljeni rad, znanstveni)
Švob Štrac, D. (2013) Prolonged exposure to benzodiazepines and alcohol: Adaptive changes of GABA-A receptors associated with development of tolerance and dependence. U: COST Action CM1103 Training School “Structure- based drug design for diagnosis and treatment of neurological diseases”.
@article{article, author = {\v{S}vob \v{S}trac, Dubravka}, year = {2013}, keywords = {benzodiazepines, alcohol, GABA-A receptors, tolerance and dependence}, title = {Prolonged exposure to benzodiazepines and alcohol: Adaptive changes of GABA-A receptors associated with development of tolerance and dependence}, keyword = {benzodiazepines, alcohol, GABA-A receptors, tolerance and dependence}, publisherplace = {Istanbul, Turska} }
@article{article, author = {\v{S}vob \v{S}trac, Dubravka}, year = {2013}, keywords = {benzodiazepines, alcohol, GABA-A receptors, tolerance and dependence}, title = {Prolonged exposure to benzodiazepines and alcohol: Adaptive changes of GABA-A receptors associated with development of tolerance and dependence}, keyword = {benzodiazepines, alcohol, GABA-A receptors, tolerance and dependence}, publisherplace = {Istanbul, Turska} }

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