Naslov
Elucidation of metal ion-binding sites in proteins

Autori
Tomić, Sanja ; Tomić, Antonija ; Brkić, Hrvoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th Central Europe Conference - Abstracts of scientific contributions / Roberto Rizzo - Trst : Universita degli studi di Trieste, 2013, Oc15-oc15

Skup
6th Central Europe Conference

Mjesto i datum
Trst, Italija, 10.09.2013. - 13.09.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
metalni ioni ; proteini

Sažetak
Metal ions are constituents of about 40% of proteins1 where they can act as structure promoters or can take part in enzymatic reactions. Removal or replacement of one metal by another is often accompanied either by loss, or reduction, or even alternation of the enzyme catalytic potency2. Apparently knowledge of the type and number of electron donors is important for modeling an enzyme catalyzed chemical reaction as well as to clarify how specific certain metal binding sites are. We have combined the web-based platform for analysis of metal-binding sites in proteins3 and quantum mechanical – DFT calculations to reveal details of the metal binding sites in several enzymes. Herein I’ll summarize results of our theoretical studies on two dioxygenase4 and one dipeptidase.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA