Naslov
Oestrogen has protective effect on acetylcholine induced relaxation of aortic rings in diabetic rats

Autori
Čavka, Ana ; Manojlović, Dragan ; Lučić, Dejana ; Grizelj, Ivana ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum Biologorum Vol 115, Suppl 2 / Vitale, Branko ; Drenjancevic, Ines - Zagreb, 2013

Skup
3. Congress of Croatian Physiological Society and 1. Regional Congress of The Physiologycal Societies

Mjesto i datum
Rijeka, Hrvatska, 13.09.2013. - 15.09.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
oestrogen; diabetes mellitus; vascular function

Sažetak
Objective: The aims of this study were to examine the effects of ovariectomy and whether age and/or diabetes (DM) duration have effect on vascular relaxation to acetylcholine in age- matched healthy and DM non-ovariectomized (non- OVX) and ovariectomized (OVX) rats. Methods: Bilateral ovariectomy was performed and streptozotocin was used to induce diabetes mellitus in female Sprague-Dawley rat, divided into 8 groups: 12 weeks old (6 weeks DM) CONTROL, DM, OVX CONTROL, OVX DM and 16 weeks old (10 weeks DM) CONTROL, DM, OVX CONTROL, OVX DM. Thoracic aortic rings were used to test dose responses to acetylcholine (10- 9-10-5 M) after precontraction with noradrenaline. Results: While there was no significant difference in relaxation between both non-OVX 12 weeks old CONTROL and DM and 16 weeks old CONTROL and DM rats, vascular responsiveness was significantly reduced in both 12 weeks and 16 weeks old OVX DM rats compared to their age- matched CONTROLS. There was no difference in vascular response considering age and/or DM duration in both non-OVX and OVX rats. Conclusions: These results suggest that oestrogen may have protective effect on vascular relaxation in DM rats. Longer duration of DM seems not to have effect on vascular responsiveness in both non OVX and OVX rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA