Naslov
"Backdoor induction" in bioinspired asymmetric catalysis"
("Backdoor induction" in bioinspired asymmetric catalysis)

Autori
Kokan, Zoran ; Gredičak, Matija ; Jerić, Ivanka ; Kirin, Srećko I.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
E-Book of Abstracts / Rodriguez, Laura - Barcelona, 2013, P21-P21

Skup
1st Symposium on Functional Metal Complexes that Bind to Biomolecules

Mjesto i datum
Barcelona, Španjolska, 09.09.2013. - 10.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
amino acids; artificial metalloenzymes; asymmetric catalysis; metallated bioconjugates; supramolecular chemistry

Sažetak
Chiral metal complexes are used as homogeneous asymmetric catalysts very frequently. The importance of the incorporation of the chiral information as close as possible to the coordination sphere of the catalytic metal is widely accepted. In order to challenge this fundamental principle, a catalytically active metal centre that is only prochiral can be used. The chiral information is transmitted by "backdoor induction" via hydrogen bonding between distant pedant amino acids. An artificial C2-symmetrical secondary turn structure is formed that controls the chirality of the catalytic metal coordination sphere. In this communication, we present the synthesis and characterization of chiral monodentate bioconjugates L1–L3 and bidentate bioconjugates L4–L5. Rh(I) complexes with Rh(L1–L3)2 or Rh(L4–L5) stoichiometry are prepared in situ and used as catalysts in asymmetric hydrogenation of alpha, betha-dehydroamino acids with selectivity up to 81% ee. These catalysts could be models of artificial enzymes with a functional secondary coordination sphere.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA