Pregled bibliografske jedinice broj: 640895
The regions of alpha-neurotoxin binding on the extracellular part of the alpha-subunit of human acetylcholine receptor
The regions of alpha-neurotoxin binding on the extracellular part of the alpha-subunit of human acetylcholine receptor // Journal of protein chemistry, 7 (1988), 2; 173-177 doi:10.1007/BF01025247 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 640895 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The regions of alpha-neurotoxin binding on the extracellular part of the alpha-subunit of human acetylcholine receptor
Autori
Mulac-Jeričević, Biserka ; Manshouri, T. ; Yokoi, T. ; Atassi, M.Z.
Izvornik
Journal of protein chemistry (0277-8033) 7
(1988), 2;
173-177
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
acetylcholine receptor; bungarotoxin; synthetic peptides
Sažetak
A set of 18 synthetic uniform overlapping peptides spanning the entire extracellular part (residues 1-210) of the alpha-subunit of human acetylcholine receptor were studied for their binding activity of 125I-labeled alpha-bungarotoxin and cobratoxin. A major toxin-binding region was found to reside within peptide alpha 122-138. In addition, low-binding activities were obtained with peptides alpha 34-49 and alpha 194-210. It is concluded that the region within residues alpha 122-138 constitutes a universal major toxin-binding region for acetylcholine receptor of various species.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
