Naslov
Adhesion of lipid vesicles at an electrified interface

Autori
Ivošević DeNardis, Nadica

Izvornik
Institute de Pharmacologie et de Biologie Structurale, Toulouse, Francuska

Vrsta, podvrsta
Ostale vrste radova, ostalo

Godina
2013

Ključne riječi
adhesion; interfacial forces; lipid vesicle; mechanical mode; reaction kinetics model

Sažetak
Lipid vesicles are used as drug carriers for therapeutic and diagnostic needs but release mechanism in the body requires further research. Electrochemical adhesion detection presents an unique approach for in situ characterization of individual soft microparticle (lipid vesicle, living cell, organic droplet) in aqueous medium through appearance of well-defined adhesion signal due to their fast attachment, deformation and spreading at an electrified interface. Adhesion signal of vesicle contains important set of data regarding thermodynamics, kinetics of the adhesion process and reflects their collective surface properties (1). It will be demonstrated detection of adhesion signal and extraction of information stored in the signal using models, in order to better understand contribution and role of interfacial forces responsible for dynamics of particle adhesion in respect to the potential stimuli (2). 1. N. Ivošević DeNardis, V. Žutić, V. Svetličić, R. Frkanec, Adhesion signals of phospholipid vesicles at an electrified interface, J. Membrane Biol. 245 (2012) 573-582. 2. N. Ivošević DeNardis, I. Ružić, J. Pečar-Ilić, S. El Shawish, P. Ziherl, Reaction kinetics and mechanical models of liposome adhesion at charged interface, Bioelectrochemistry 88 (2012) 48–56.

Izvorni jezik
Engleski

Znanstvena područja
Geologija

POVEZANOST RADA