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Pregled bibliografske jedinice broj: 639278

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott, R.A.; ...; Polašek, Ozren; ...; Zemunik, Tatijana; ...; Rudan, Igor; ...; Barroso, I.
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways // Nature genetics, 44 (2012), 9; 991-1005 doi:10.1038/ng.2385 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 639278 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Autori
Scott, R.A. ; ... ; Polašek, Ozren ; ... ; Zemunik, Tatijana ; ... ; Rudan, Igor ; ... ; Barroso, I.

Izvornik
Nature genetics (1061-4036) 44 (2012), 9; 991-1005

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gene; glucose; glycemic

Sažetak
Through genome-wide association meta-analyses of up to 133, 010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Tatijana Zemunik (autor)

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Scott, R.A.; ...; Polašek, Ozren; ...; Zemunik, Tatijana; ...; Rudan, Igor; ...; Barroso, I.
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways // Nature genetics, 44 (2012), 9; 991-1005 doi:10.1038/ng.2385 (međunarodna recenzija, članak, znanstveni)
Scott, R., ..., Polašek, O., ..., Zemunik, T., ..., Rudan, I., ... & Barroso, I. (2012) Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature genetics, 44 (9), 991-1005 doi:10.1038/ng.2385.
@article{article, author = {Scott, R.A. and Pola\v{s}ek, Ozren and Zemunik, Tatijana and Rudan, Igor and Barroso, I.}, year = {2012}, pages = {991-1005}, DOI = {10.1038/ng.2385}, keywords = {gene, glucose, glycemic}, journal = {Nature genetics}, doi = {10.1038/ng.2385}, volume = {44}, number = {9}, issn = {1061-4036}, title = {Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways}, keyword = {gene, glucose, glycemic} }
@article{article, author = {Scott, R.A. and Pola\v{s}ek, Ozren and Zemunik, Tatijana and Rudan, Igor and Barroso, I.}, year = {2012}, pages = {991-1005}, DOI = {10.1038/ng.2385}, keywords = {gene, glucose, glycemic}, journal = {Nature genetics}, doi = {10.1038/ng.2385}, volume = {44}, number = {9}, issn = {1061-4036}, title = {Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways}, keyword = {gene, glucose, glycemic} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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