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Pregled bibliografske jedinice broj: 639277

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Köttgen, Anna; ...; Zemunik, Tatijana; ...; Kolčić, Ivana; ...; Polašek, Ozren; ...; Rudan, Igor; ...; Gieger, C.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations // Nature genetics, 45 (2013), 2; 145-154 doi:10.1038/ng.2500 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 639277 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Autori
Köttgen, Anna ; ... ; Zemunik, Tatijana ; ... ; Kolčić, Ivana ; ... ; Polašek, Ozren ; ... ; Rudan, Igor ; ... ; Gieger, C.

Izvornik
Nature genetics (1061-4036) 45 (2013), 2; 145-154

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
serum; urate; gene

Sažetak
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140, 000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Tatijana Zemunik (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Ivana Kolčić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Köttgen, Anna; ...; Zemunik, Tatijana; ...; Kolčić, Ivana; ...; Polašek, Ozren; ...; Rudan, Igor; ...; Gieger, C.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations // Nature genetics, 45 (2013), 2; 145-154 doi:10.1038/ng.2500 (međunarodna recenzija, članak, znanstveni)
Köttgen, A., ..., Zemunik, T., ..., Kolčić, I., ..., Polašek, O., ..., Rudan, I., ... & Gieger, C. (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature genetics, 45 (2), 145-154 doi:10.1038/ng.2500.
@article{article, author = {K\"{o}ttgen, Anna and Zemunik, Tatijana and Kol\v{c}i\'{c}, Ivana and Pola\v{s}ek, Ozren and Rudan, Igor and Gieger, C.}, year = {2013}, pages = {145-154}, DOI = {10.1038/ng.2500}, keywords = {serum, urate, gene}, journal = {Nature genetics}, doi = {10.1038/ng.2500}, volume = {45}, number = {2}, issn = {1061-4036}, title = {Genome-wide association analyses identify 18 new loci associated with serum urate concentrations}, keyword = {serum, urate, gene} }
@article{article, author = {K\"{o}ttgen, Anna and Zemunik, Tatijana and Kol\v{c}i\'{c}, Ivana and Pola\v{s}ek, Ozren and Rudan, Igor and Gieger, C.}, year = {2013}, pages = {145-154}, DOI = {10.1038/ng.2500}, keywords = {serum, urate, gene}, journal = {Nature genetics}, doi = {10.1038/ng.2500}, volume = {45}, number = {2}, issn = {1061-4036}, title = {Genome-wide association analyses identify 18 new loci associated with serum urate concentrations}, keyword = {serum, urate, gene} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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