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Pregled bibliografske jedinice broj: 639276

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

Lu, Y.; ...; Rudan, Igor; Vatavuk, Zoran; ...; Polašek, Ozren; ...; Wong, Tien Y.
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus // Nature genetics, 45 (2013), 2; 155-163 doi:10.1038/ng.2506 (međunarodna recenzija, članak, znanstveni)

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Naslov
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

Autori
Lu, Y. ; ... ; Rudan, Igor ; Vatavuk, Zoran ; ... ; Polašek, Ozren ; ... ; Wong, Tien Y.

Izvornik
Nature genetics (1061-4036) 45 (2013), 2; 155-163

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
thickness; keratoconus; gene

Sažetak
Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20, 000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (P < 5 × 10(-8)). We further showed that 2 CCT-associated loci, FOXO1 and FNDC3B, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6, 085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4-1.88, P = 2.7 × 10(-10), and rs4894535 in FNDC3B had OR = 1.47, 95% CI = 1.29-1.68, P = 4.9 × 10(-9)). FNDC3B was also associated with primary open-angle glaucoma (P = 5.6 × 10(-4) ; tested in 3 cohorts with 2, 979 cases and 7, 399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Zoran Vatavuk (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Lu, Y.; ...; Rudan, Igor; Vatavuk, Zoran; ...; Polašek, Ozren; ...; Wong, Tien Y.
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus // Nature genetics, 45 (2013), 2; 155-163 doi:10.1038/ng.2506 (međunarodna recenzija, članak, znanstveni)
Lu, Y., ..., Rudan, I., Vatavuk, Z., ..., Polašek, O., ... & Wong, T. (2013) Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nature genetics, 45 (2), 155-163 doi:10.1038/ng.2506.
@article{article, author = {Lu, Y. and Rudan, Igor and Vatavuk, Zoran and Pola\v{s}ek, Ozren and Wong, Tien Y.}, year = {2013}, pages = {155-163}, DOI = {10.1038/ng.2506}, keywords = {thickness, keratoconus, gene}, journal = {Nature genetics}, doi = {10.1038/ng.2506}, volume = {45}, number = {2}, issn = {1061-4036}, title = {Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus}, keyword = {thickness, keratoconus, gene} }
@article{article, author = {Lu, Y. and Rudan, Igor and Vatavuk, Zoran and Pola\v{s}ek, Ozren and Wong, Tien Y.}, year = {2013}, pages = {155-163}, DOI = {10.1038/ng.2506}, keywords = {thickness, keratoconus, gene}, journal = {Nature genetics}, doi = {10.1038/ng.2506}, volume = {45}, number = {2}, issn = {1061-4036}, title = {Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus}, keyword = {thickness, keratoconus, gene} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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