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Pregled bibliografske jedinice broj: 639275

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Verhoeven, V.J.M.; ...; Rudan, Igor; ...; Polašek, Ozren; Vatavuk, Zoran; ...; Hammond, C.J.
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia // Nature genetics, 45 (2013), 3; 314-318 doi:10.1038/ng.2554 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 639275 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Autori
Verhoeven, V.J.M. ; ... ; Rudan, Igor ; ... ; Polašek, Ozren ; Vatavuk, Zoran ; ... ; Hammond, C.J.

Izvornik
Nature genetics (1061-4036) 45 (2013), 3; 314-318

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gene; myopia; refractive

Sažetak
Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The CREAM consortium conducted genome-wide meta-analyses, including 37, 382 individuals from 27 studies of European ancestry and 8, 376 from 5 Asian cohorts. We identified 16 new loci for refractive error in individuals of European ancestry, of which 8 were shared with Asians. Combined analysis identified 8 additional associated loci. The new loci include candidate genes with functions in neurotransmission (GRIA4), ion transport (KCNQ5), retinoic acid metabolism (RDH5), extracellular matrix remodeling (LAMA2 and BMP2) and eye development (SIX6 and PRSS56). We also confirmed previously reported associations with GJD2 and RASGRF1. Risk score analysis using associated SNPs showed a tenfold increased risk of myopia for individuals carrying the highest genetic load. Our results, based on a large meta-analysis across independent multiancestry studies, considerably advance understanding of the mechanisms involved in refractive error and myopia

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Zoran Vatavuk (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Verhoeven, V.J.M.; ...; Rudan, Igor; ...; Polašek, Ozren; Vatavuk, Zoran; ...; Hammond, C.J.
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia // Nature genetics, 45 (2013), 3; 314-318 doi:10.1038/ng.2554 (međunarodna recenzija, članak, znanstveni)
Verhoeven, V., ..., Rudan, I., ..., Polašek, O., Vatavuk, Z., ... & Hammond, C. (2013) Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nature genetics, 45 (3), 314-318 doi:10.1038/ng.2554.
@article{article, author = {Verhoeven, V.J.M. and Rudan, Igor and Pola\v{s}ek, Ozren and Vatavuk, Zoran and Hammond, C.J.}, year = {2013}, pages = {314-318}, DOI = {10.1038/ng.2554}, keywords = {gene, myopia, refractive}, journal = {Nature genetics}, doi = {10.1038/ng.2554}, volume = {45}, number = {3}, issn = {1061-4036}, title = {Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia}, keyword = {gene, myopia, refractive} }
@article{article, author = {Verhoeven, V.J.M. and Rudan, Igor and Pola\v{s}ek, Ozren and Vatavuk, Zoran and Hammond, C.J.}, year = {2013}, pages = {314-318}, DOI = {10.1038/ng.2554}, keywords = {gene, myopia, refractive}, journal = {Nature genetics}, doi = {10.1038/ng.2554}, volume = {45}, number = {3}, issn = {1061-4036}, title = {Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia}, keyword = {gene, myopia, refractive} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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