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Pregled bibliografske jedinice broj: 639274

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt, S.I.; ...; Polašek, Ozren; ...; Rudan, Igor; ...; Ingelsson, Erik
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture // Nature genetics, 45 (2013), 5; 501-512 doi:10.1038/ng.2606 (međunarodna recenzija, članak, znanstveni)

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Naslov
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Autori
Berndt, S.I. ; ... ; Polašek, Ozren ; ... ; Rudan, Igor ; ... ; Ingelsson, Erik

Izvornik
Nature genetics (1061-4036) 45 (2013), 5; 501-512

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gene; stature; height

Sažetak
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263, 407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Berndt, S.I.; ...; Polašek, Ozren; ...; Rudan, Igor; ...; Ingelsson, Erik
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture // Nature genetics, 45 (2013), 5; 501-512 doi:10.1038/ng.2606 (međunarodna recenzija, članak, znanstveni)
Berndt, S., ..., Polašek, O., ..., Rudan, I., ... & Ingelsson, E. (2013) Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature genetics, 45 (5), 501-512 doi:10.1038/ng.2606.
@article{article, author = {Berndt, S.I. and Pola\v{s}ek, Ozren and Rudan, Igor and Ingelsson, Erik}, year = {2013}, pages = {501-512}, DOI = {10.1038/ng.2606}, keywords = {gene, stature, height}, journal = {Nature genetics}, doi = {10.1038/ng.2606}, volume = {45}, number = {5}, issn = {1061-4036}, title = {Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture}, keyword = {gene, stature, height} }
@article{article, author = {Berndt, S.I. and Pola\v{s}ek, Ozren and Rudan, Igor and Ingelsson, Erik}, year = {2013}, pages = {501-512}, DOI = {10.1038/ng.2606}, keywords = {gene, stature, height}, journal = {Nature genetics}, doi = {10.1038/ng.2606}, volume = {45}, number = {5}, issn = {1061-4036}, title = {Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture}, keyword = {gene, stature, height} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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