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Pregled bibliografske jedinice broj: 639273

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

den Hoed M.; ...; Polašek, Ozren; ...; Rudan, Diana; ...; Rudan, Igor; ...; Loor, R.J.F.
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders // Nature genetics, 45 (2013), 6; 621-631 doi:10.1038/ng.2610 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 639273 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Autori
Den Hoed M. ; ... ; Polašek, Ozren ; ... ; Rudan, Diana ; ... ; Rudan, Igor ; ... ; Loor, R.J.F.

Izvornik
Nature genetics (1061-4036) 45 (2013), 6; 621-631

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rhytm; conduction; gene

Sažetak
Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181, 171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Diana Rudan (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

den Hoed M.; ...; Polašek, Ozren; ...; Rudan, Diana; ...; Rudan, Igor; ...; Loor, R.J.F.
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders // Nature genetics, 45 (2013), 6; 621-631 doi:10.1038/ng.2610 (međunarodna recenzija, članak, znanstveni)
Den Hoed M., ..., Polašek, O., ..., Rudan, D., ..., Rudan, I., ... & Loor, R. (2013) Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature genetics, 45 (6), 621-631 doi:10.1038/ng.2610.
@article{article, author = {Pola\v{s}ek, Ozren and Rudan, Diana and Rudan, Igor and Loor, R.J.F.}, year = {2013}, pages = {621-631}, DOI = {10.1038/ng.2610}, keywords = {rhytm, conduction, gene}, journal = {Nature genetics}, doi = {10.1038/ng.2610}, volume = {45}, number = {6}, issn = {1061-4036}, title = {Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders}, keyword = {rhytm, conduction, gene} }
@article{article, author = {Pola\v{s}ek, Ozren and Rudan, Diana and Rudan, Igor and Loor, R.J.F.}, year = {2013}, pages = {621-631}, DOI = {10.1038/ng.2610}, keywords = {rhytm, conduction, gene}, journal = {Nature genetics}, doi = {10.1038/ng.2610}, volume = {45}, number = {6}, issn = {1061-4036}, title = {Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders}, keyword = {rhytm, conduction, gene} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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