Naslov
Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients

Autori
Bulum, Tomislav ; Kolarić, Branko ; Prkačin, Ingrid ; Duvnjak, Lea

Izvornik
Collegium antropologicum (0350-6134) 37 (2013), 3; 771-776

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
type 1 diabetes; serum lipids; renal function; glomerular filtration rate

Sažetak
Studies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function. We investigated the associations of serum lipids, including total, LDL, HDL, VLDL cholesterol, and triglyceride levels with estimated glomerular filtration rate (eGFR) in type 1 diabetic patients. Study included 313 normoalbuminuric type 1 diabetic patients with normal or mild decrease (eGFR > 60 ml/min per 1.73 m2) renal function and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was significantly associated with total, LDL, and HDL cholesterol (r=-0.21, -0.18, and -0.17, respectively, for all p <0.05). Stratifying serum lipids for degree of eGFR, levels of total, LDL, and HDL cholesterol were inversely related to eGFR, but trends were significant only for total (5.1 vs 5.0 and 4.6 mmol/L) and LDL cholesterol (2.9 vs 2.8 and 2.4 mmol/L). We have detected an association between eGFR and lipid abnormalities in type 1 diabetes in early stages. The study was conducted in patients with no therapeutic intervention. This may suggest that lipid abnormalities may play a role in the pathogenesis of renal impairment in type 1 diabetic patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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