Naslov
Pseudopolymorphic phase transition of lamotrigine:Theophilline cocrystals

Autori
Lekšić, Edislav ; Bučar, Dejan-Krešimir ; Meštrović, Ernest

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
23rd Croatian Meeting of Chemist and Chemical Engineers / - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013

Skup
23rd Croatian Meeting of Chemist and Chemical Engineers

Mjesto i datum
Osijek, Hrvatska, 21.04.2013. - 24.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
CoCrystal; Lamotrigine; Drug-drug cocrystals; tTherapeutic effect

Sažetak
The development of drug-drug cocrystals for combination therapy is a new and dynamic area in drug development, as it has been shown that two active pharmaceutical ingradients (APIs) can have a significantly better therapeutic effect when administrated together. Here we report how a pharmaceutically acceptable cocrystal, based on lamotrigine (lam) and theophylline (theo), can be produced through an unusual pseudopolymorphic transition (Scheme 1). Moreover, we show that the cocrystals cannot be obtained in large scales by conventionaly solution crystallization methods. Our study has also resulted in resolving the crystal structures of multi-component cocrystal solvates, namely lam:theo:DMF and lam:theo:DMSO:H2O. The three-component cocrystals were shown to convert into four-component cocrystal hydrates based on lam, theo, DMF/DMSO and H2O upon exposure to humid conditions, and finally transform into a three-component cocrystal hydrate, lam:theo:H2O. Single crystal X-ray diffraction studies revealed that the lam:theo cocrystals exhibit a great variety of supramolecular synthons in the solid state.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA