Naslov
Ex vivo determination of IFN-γ in health care workers
(Određivanje interferona gama ex vivo u zdravstvenih radnika)

Autori
Dodig, Slavica ; Zrinski Topić Renata ; Živčić, Jadranka ; Pavić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Biochemia medica - Symposium lectures abstracts / - Zagreb : Medicinska naklada, 2012, A20-A20

Skup
23rd Symposium Croatian Society for Medical Biochemistry and Laboratory Medicine. Tuberculous infection – continuous challenge

Mjesto i datum
Zagreb, Hrvatska, 22.09.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
interferon gama; IGRA-test; latentna tuberkulozna infekcija; zdravstveni radnici
(interferon gamma; IGRA-test; latent tuberculosis infection; health care workers)

Sažetak
Detection and follow-up the blood test determining interferon-gamma (IFN-γ) released from effector T-lymphocytes (interferon-gamma release assay, IGRA) upon stimulation with M. tuberculosis specific peptides should be performed in subjects at an increased risk of M. tuberculosis infection such as health care workers (HCW) in chest hospital and immunocompromised subjects. Two cases of HCW with type 1 diabetes mellitus (T1DM) and positive anti-thyroglobulin (anti-Tg) autoantibodies, respectively, are presented. Case 1: a 46 year-old female HCW who has been having T1DM for 20 years underwent routine screening for Latent tuberculosis infection (LTBI). She was not acutely ill, she had normal body temperature, was eupneic and lung auscultation show normal breathing. Tuberculin skin test (TST) was negative and IGRA was positive (4.7 kIU/L). Positive IGRA indicated the LTBI, while TST result was false negative. Antituberculosis prophilaxis was not used. Case 2: a 57 year-old clinically healthy female was included in an annual screeding for LTBI. Initial testing showed positive TST and IGRA (5.2 kIU/L) and elevated levels of anti-Tg (86.4 kIU/L). She was free from acute disease, afebrile, eupneic, with normal breath sounds on auscultation. One year later IGRA was still positive. Antituberculosis prophilaxis was not used. Although isoniazid prophylaxis was not used in these subjects, tuberculosis did not develop during the 4-year follow-up period.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija

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