Naslov
Indeterminate results of ex vivo Interferon-gamma determination in non-immunosuppressed children
(Neodredivi rezultati interferona gama ex vivo u imuno-nesuprimirane djece)

Autori
Pavić, Ivan ; Zrinski Topić, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Biochemia medica - Symposium lectures abstracts / - Zagreb : Medicinska naklada, 2012, A20-A20

Skup
23rd Symposium Croatian Society for Medical Biochemistry and Laboratory Medicine. Tuberculous infection – continuous challenge

Mjesto i datum
Zagreb, Hrvatska, 22.09.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
interferon gama; IGRA-test; imuno-nekosuprimirano dijete
(interferon gamma; IGRA-test; non-immunosuppressed child)

Sažetak
Immunosuppressed individuals due to pathologic conditions (eg. HIV infection, hematologic malignancies, chronic renal failure) or therapeutic procedures (eg. organ transplantation, chemotherapy, immunosuppressive therapy with tumor necrosis factor α (TNF-α), therapy with systemic corticosteroids) are at high risk for reactivation of latent tuberculosis infection (LTBI), and require timely identification. Laboratory diagnosis of LTBI is based on the blood test determining interferon-gamma (IFN-γ) released from effector T-lymphocytes (interferon-gamma release assay, IGRA) upon stimulation with M. tuberculosis specific peptides. Two children with indeterminate results of IGRA are presented. They were free from congenital or acquired immunodeficiency disorders, as shown by their history data, clinical examination and laboratory findings. Case 1: a 15-month-old male infant was referred for testing because of cough and febrile condition persisting for a week before admission. Status: febrile, eupneic, pale, tachycardia, serous nasal discharge, pharyngeal congestion, normal breath sounds over lungs on auscultation. Examination and test findings indicated the diagnosis of pneumonia. Case 2: a 5.5-year-old female child was referred for testing due to persistent cough and subfebrile condition with serous nasal discharge for three days before admission. She was positive for contact with tuberculosis patient, as her uncle has been treated for microbiologically positive lung tuberculosis 3 years before. Examination and test findings indicated the diagnosis of lung tuberculosis. As no indeterminate results were found on repeat IGRA, it was assumed that acute bacterial inflammation (acute pneumonia or tuberculosis), could produce the indeterminate results recorded on initial testing. In acute inflammationa IGRA should be delayed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA