Naslov
Tuberculosis and anti-cytokine therapy
(Tuberkuloza i anticitokinska terapija)

Autori
Anić, Branimir ; Cerovec, Mislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Biochemia medica - Symposium lectures abstracts / - Zagreb : Medicinska naklada, 2012, A18-A18

Skup
23rd Symposium Croatian Society for Medical Biochemistry and Laboratory Medicine. Tuberculous infection – continuous challenge

Mjesto i datum
Zagreb, Hrvatska, 22.09.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
tuberculosis; anti-cytokine therapy
(tuberkuloza; anticitokinska terapija)

Sažetak
Patients with rheumatoid arthritis, RA, have greater rates of infections comparing with general population. Most common infectons are respiratory tract infections and also skin and soft tissue infections. Treatment guidlines imply decisive and agressive immunosupressive treatment early in the course of the disease, just after the diagnosis of RA is established. The introduction of biological drugs has increased the risk of tuberculosis, especially in the case with the use of drugs that inhibit tumor necrosis factor alpha, TNF-α. TNF-α, especially transmembrane TNF-α, plays an important role in innate immunity and immune defense focused on Mycobacterium tuberculosis. The mechanisms that are inhibited by using anti-TNF-α drugs are important for maintaining the latent phase of tuberculosis (LTBI - latent tuberculosis infection). The key role of TNF-α in the defense against tuberculosis has been showed in the experiments with knock-out mice which showed that the cytokine TNF-α is necessary for granuloma formation and its maintenance, and that it have equally important role in the macrophages activation. Excessive inhibition of TNF-α leads to exacerbation of TB. The importance of careful screening of patients for tuberculosis before the introduction of biological drugs in to the treatment of inflammatory rheumatic diseases was also recognized by the Croatian Society for Rheumatology and the Croatian Respiratory Society, so the joint guidelines for the diagnosis of latent tuberculosis in vaccinated patients before the introduction of anti-TNF-α therapy were adopted. Early introduction and application of these guidelines results in a low occurrence of tuberculosis in Croatian patients on biological therapies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA