Naslov
Ganglioside GM3 synthase gene is down-regulated in white blood cells of PTSD patients

Autori
Ćurić, Goran ; Wagner, Jasenka ; Braš, Marijana ; Gašparović, Marta ; Pavlinić, Dinko ; Lauc, Gordan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
The 7th ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine: The book of abstracts / Vuk-Pavlović, Stanimir ; Primorac, Dragan ; Schanfield, Moses - Zagreb : International Society for Applied Biological Sciences (ISABS), 2011, 174-174

Skup
The 7th ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine

Mjesto i datum
Bol, Hrvatska, 20.06.2011. - 24.06.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ganglioside; stress; sialylation; glycosylation; immune cell

Sažetak
Gangliosides are sialic acid bearing glycosphingolipids and sialic acid residues have important role in recognition events in immune cell and immune response pathways. Blood immune cells are directly and indirectly under control of hypothalamus-pituitary-adrenal (HPA) axis. Alterations in HPA signaling and immune system are characteristic of the posttraumatic stress disorder (PTSD). Interaction between psychological processes, nervous and immune system in PTSD is poorly understood. We studied expression of genes for three ganglioside sialyltransferases: ganglioside GM3 synthase (ST3 beta-galactoside alpha-2, 3-sialyltransferase 5 - ST3GAL5), ST3 beta-galactoside alpha-2, 3-sialyltransferase 2 (ST3GAL2) and ST6 (alpha-N-acetyl-neuraminyl-2, 3- beta-galactosyl-1, 3)-Nacetylgalactosaminide alpha-2, 6-sialyltransferase 3 (ST6GALNAC3), in white blood cells of 117 PTSD-affected and 52 PTSD-unaffected veterans. We established down- regulation of ST3GAL5 gene in PTSD patients (P<0.001). ST3GAL5 primarily regulates amount of ganglioside GM3, ubiquitous ganglioside in different tissues cells’ membranes and precursor of almost all complex gangliosides. Due to important role of ganglioside GM3 and complex gangliosides in immune cell recognition processes, down-regulation of ST3GAL5 may have important functional implications and reflect either predisposition, or be a pathophysiological consequence of PTSD. We further demonstrate that ganglioside GD1Į, enzymatic product of ST6GALNAC3, might have important role in white blood cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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