Naslov
Genuine and Cross-Reactive Peanut Components in Birch-Sensitive Preschool Children

Autori
Voskresensky-Baričić, Tamara ; Dodig, Slavica

Izvornik
LabMedicine (0007-5027) 44 (2013), 3; 210-214

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allergy; birch; IgE; component-resolved diagnosis; microarray; peanut

Sažetak
Component-resolved diagnosis (CRD), enables the identification of genuine and cross-reactive allergen molecules. The aim of this study was to compare the results of the skin prick test (SPT), specific immunoglobulin E (sIgE), and CRD in–birch-pollen sensitive preschool children. The subjects’ mothers answered a standardized questionnaire about clinical manifestations after peanut ingestion by their children. The sIgEs were determined by the fluorescence enzyme immunoassay, and CRD by microarray technique. Children with birch-positive/peanut-positive SPT developed generalized urticaria or oral allergy syndrome within 30 minutes after ingesting peanuts. Discordant results between peanut-SPT and peanut-sIgE, and between peanut-sIgE and peanut-genuine-CRD, respectively, were confirmend. The results of CRD distinguished genuine from cross-reactive allergens. The SPT and sIgE may detect sensitization and cosensitization to allergen extracts, and CRD may detect sensitization and cosensitization to genuine and cross-reactive allergen components in preschool children. Further investigations are required to ascertain the causes of discordant results.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA