Naslov
Immunogenetic profile of psoriasis vulgaris type I in Croatian patients

Autori
Pašić, Aida ; Dražić, Vesna ; Grahovac, Blaženka ; Lipozenčić Jasna ; Bingulac-Popović, Jasna ; Basta- Juzbašić, Aleksandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 2nd International Congress Psoriasis from gene to clinic ; u: British Journal of Dermatology / - London : Delhi : British Association of Dermatologists, 1999, 981-981

Skup
2nd International Congress Psoriasis from gene to clinic (2 ; 1999)

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 02.12.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
immunogenetic of psoriasis ; HL-A association in psoriasis ; haplotypes in psoriatics

Sažetak
Psoriasis vulgaris is a skin disease with an immunological and genetic background. To further evaluate the nature of HLA associations with psoriasis, we studied the allelic frequences and haplotypes of HLA class I and class II in patients with psoriasis type I. We used serological HLA typing of DRB1, DQA1 and DQB1 loci in 46 patients with psoriasis vulgaris (24 male, 22 female). The control group consisted of 92 randomly selected healthy blood donors. The haplotypes most frequently distinguished between patients with psoriasis and controls were carrying A*0201 (P=0.0091, RR=20.09), Cw+0602(P<0.00005 ; RR8.58). Analysis of haplotypes in patient families revealed the following to be candidates for psoriatic haplotypes in Croatian patients: A*0201-B*13-Cw*0602-DRV1*0701-DQA1*0201- DQB1*03 and A*02-B*5701-Cw*0602.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA