Naslov
Relationship between interleukin-6 and cardiac involvement in systemic sclerosis

Autori
Jurisić, Zrinka ; Martinović Kaliterna, Dušanka ; Marasović Krstulović, Daniela ; Perković, Dijana ; Tandara, Leida ; Salamunić, Ilza ; Carević, Vedran

Izvornik
Rheumatology (1462-0324) 52 (2013), 7; 1298-1302

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
systemic sclerosis; cardiac involvement; interleukin-6;

Sažetak
Objectives were to explore the relationship between IL-6 and echocardiographic abnormalities, and N-terminal probrain natriuretic peptide (NT-proBNP) levels in SSc patients and to correlate tested parameters with European Scleroderma Activity (EUSTAR) score. This case-control study include 31 SSc patients with preserved left ventricular ejection fraction (LVEF)and 32 matched healthy controls. Serum IL-6 and NT-proBNP levels were measured and subjects were evaluated by conventional and pulsed-wave tissue Doppler echocardiography. The level of IL-6 was significantly increased in patients with SSc (3.2 vs. 2.2 pg/ml, P < 0.001). SSc patients had significantly lower values of LV systolic (7.7 vs. 9.25 cm/s, P < 0.001) and early diastolic (8.7 vs. 10.3 cm/s, P = 0.014) myocardial velocities and higher E/e (9.04 vs. 7.37, P = 0.001) ratio, although there was no between-group difference according to LVEF (68% vs 65%, P = 0.248). On evaluating the right ventricle there was no significant between-group difference in systolic tricuspid annular velocity (13 vs 13.9 cm/s, P = 0.105), but the peak early diastolic velocity was significantly lower (11.7 vs 13.6, P = 0.044) and E/e was significantly higher (4.3 vs 3.38, P = 0.008) in SSc patients. IL-6 level showed correlation with LV mean e (r = -0.57, P = 0.001), E/e (r = 0.55. P = 0.001) and proBNP (r = 0.52, P = 0.003). EUSTAR score correlated with LV E/e (r = 0.48, P = 0.006), mean e (r = -0.67, P < 0.001), mean s (r = -0.51, P = 0.004), NT-proBNP (r = 0.60, P < 0.001) and IL-6 (r = 0.79, P < 0.001). IL-6 level is increased in patients with SSc and significantly correlates with LV diastolic dysfunction, NT-proBNP and EUSTAR score. These results support the role of IL-6 in the development of cardiac disease in SSc patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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