Naslov
Primary Hypertrophic Osteoarthropathy : Clinical, Radiologic, and Scintigraphic Characteristics

Autori
Jajić, Zrinka ; Jajić, Ivo ; Nemčić, Tomislav

Izvornik
Archives of medical research (0188-4409) 32 (2001), 2; 136-142

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
primary hypertrophic osteoarthropathy ; pachydermoperiostosis ; clinical ; radiological ; scintigraphic features

Sažetak
Aim was to establish clinical and imaging characteristics of primary hypertrophic osteoarthropathy (PHO). A group of 76 patients (71 men and 5 women) with primary hypertrophic osteoarthropathy was examined. The extensive history and the status of the locomotor system were determined in all patients. Radiological and scintigraphic examinations of the bones, thermography, capillaroscopy, gastroscopy and histological analysis were also performed. The family history was positive in all 55 patients (100%) summoned for a check-up. Finger clubbing on the hands and feet as well as positive Schamroth’s test was found in all patients, hyperhidrosis in 65 (85.5%), seborrhea in 39 (51%) and involvement of the joints in 52 (68.5%) patients. Histological analysis in 18 (23.7%) patients predominantly showed periarticular oedema and moderately cellular activity. Periostosis of the long bones was also found in all patients, while scintigraphy, performed in 44 patients, was positive in 18 (33.5%) patients in the active phase of the disease. Thermography, performed in 10 patients, ranged from hypothermia to thermal amputation of the feet and hands. Capillaroscopy of the hands and feet in 47 (61.8%) patients showed changes in the small blood vessels. Gastroscopy indicated abnormalities (ulcer and hypertrophic gastritis) in 21 patients (27.6%). PHO has special clinical and radiographic manifestations (finger clubbing and periostosis of the long bones), which are associated with some minor manifestations. Development of the disease is gradual and takes up to 20 years and requires a special diagnostic assessment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA