Naslov
Ochratoxin A in human sera in the area with endemic nephropathy in Croatia

Autori
Radić, Božica ; Fuchs, Radovan ; Peraica, Maja ; Lucić, Ana

Izvornik
Toxicology letters (0378-4274) 91 (1997), 2; 105-109

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ochratoxin A; kidney disease; endemic; nephropathy

Sažetak
Ochratoxin A (OA) is neprotoxic fungal metabolite (mycotoxin) occurring in foodstuffs. The compound is causally associated with myxotocin porcine nephropathy, a disease comparable with a human kidney disease called endemic nephropathy (EN). In this paper we presented results obtained over a 10-year period in the hyperendemic village Kaniža and in control villages where no clinical cases of nephropathy had been found. In the hyperendemic village Kaniža and non-endemic villages the incidence of OA in human blood was up to 4.5 % (range 2-50 ng/ml) and up to 2.4 % (range 2-10 ng/ml), respectively. Almost all samples of food and feed, collected randomly in the hyperendemic village were found to contain OA. Considering marked exposure to OA in Kaniža, it was assumed that incidence of EN in this population could be related to OA contamination of food and feed.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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