Naslov
Mitochondrial DNA variability in Macedonians and Macedonian Romani: implication to the role in human forensic identification

Autori
Havaš Auguštin, Dubravka ; Novokmet, Natalija ; Šarac, Jelena ; Šarić, Tena ; Cvjetan, Svjetlana ; Efremovska, Ljudmila ; Đorđević, Dobrivoje ; Missoni, Saša ; Villems, Richard ; Rudan, Pavao

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
PROGRAM AND ABSTRACTS The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine / Vuk-Pavlović, Stanimir ; Primorac, Dragan ; Schanfield, Moses - Zagreb : International Society for Applied Biological Sciences (ISABS), 2013, 215-215

ISBN
978-953-57695-0-7

Skup
The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine

Mjesto i datum
Split, Hrvatska, 24.06.2013. - 28.06.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mitochondrial DNA; Macedonians; Macedonian Romani; haplogroup diversity; forensic identification

Sažetak
In this study we have analyzed a mitochondrial DNA diversity in a sample of 140 unrelated autochthonous Macedonians and 159 Macedonian Romany, representing different ethnical groups residing within the same country of Republic of Macedonia. Based on high resolution analysis of both coding and non-coding regions of mitochondrial genomes, to each of the sample haplogroup and subhaplogroup affiliation was determined. Population of Macedonians represent quite typical European population, with highest frequency of haplogroup H (42.85%), followed by hg U (17.86%), T (11.43%), J (7.85%) and K(3.57%). The other, less frequent haplogoups, also take part in shaping the maternal genetic pool of this population. On the other hand Macedonian Romani, as an example of endogamous population of Indian origin, shows significant departure from haplogruop composition and frequencies when compared to Macedonians. The highest frequency represent M5a1 haplogroup (38.36%), untypical for any European population, but very common among Indian and Romany populations. Second most frequent haplogroup is hg H (22.64%), but only two haplotypes of hg H20 and H7a1 encompass one half of this haplogroup’s diversity. Hg X2 (mostly represented by X2e1), present with less than 1% in typical European population makes more than 10% of maternal gene pool of Macedonian Romany population. This data could have their potential role in human identification as an additional tool in forensic science community.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Etnologija i antropologija

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