Naslov
Povezanost srednjeg volumena trombocita i ukupnog kardiovaskularnog rizika
(Correlation between mean platelet volume and total risk of cardiovascular disease)

Autori
Marković, Domagoj

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Medicinski fakultet

Mjesto
Split

Datum
04.07

Godina
2013

Stranica
23

Mentor
Fabijanić, Damir

Ključne riječi
Platelets; Cardiovascular risk; Atherosclerosis

Sažetak
Introduction: Association between mean platelet volume (MPV) and single cardiovascular diseases (CVD) risk factors has previously been tested. The aim of our study was to evaluate the association between MPV and total risk of CVD. Materials and Methods: In 216 consecutive outpatients referred to cardiology examination because of multiple CVD risk factors total CVD risk was estimated according to the Framingham Risk Score (FRS) as a low (<10%), intermediate (11-19%), and high (>20%). Additionally, FRS was adjusted for triglycerides (TG), body mass index (BMI) and a family history of CVD, important CVD risk factors which are not included in FRS equation. Also, CVD risk was estimated according to tertile of MPV (<8.3, 8.3-9.1, >9.1 fL, respectively). Correlation between hs-CRP and FRS has been used as confirmation that our study hypothesis was properly set. Results: MPV did not correlate with individual CVD risk factors or with FRS, either before, nor after adjustment for additionally CVD risk factors. Significant correlation between MPV and total CV risk was observed only in the adjusted high FRS group ; namely, for persons in tertile 3 were noted doubled increase in CVD risk (OR 2.2 ; 95% CI 1.05-4.64 ; p=0.038). In comparison, there was a strong linear correlation between hs-CRP and unadjusted (r=0.203, p=0.004) and adjusted (r=0.383, p<0.001) FRS. Conclusion: Correlation between MPV with only high total CVD risk suggest increased platelet activity primary as consequence and sign of the atherosclerotic vascular damage. Linear correlation between hs-CRP with FRS confirm inflammation as an important mechanism of atherogenesis,

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA