Naslov
Equal response of adolescent monozygotic twins suffering from a first episode of schizophrenia to a risperidone long-acting injectable antipsychotic

Autori
Petrić, Daniela ; Vučić Peitl, Marija ; Peitl, Vjekoslav ; Prološčić, Joško ; Frančišković, Tanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract CD-ROM / WFSBP - Kyoto : World Federation of Societies of Biological Psychiatry, 2013, N.a.-n.a.

Skup
11th World Congress of Biological Psychiatry

Mjesto i datum
Kyoto, Japan, 23.06.2013. - 27.06.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
twins ; schizophrenia ; long acting drugs

Sažetak
Objective Aim of the research was to examine the treatment response to a risperidone long- acting injectable antipsychotic of adolescent monozygotic female twins suffering from a first episode of schizophrenia. Twin research studies performed so far showed high concordance rated for schizophrenia, which are as high as 40-50% for monozygotic twins (Mata et al, 2001 ; Jakovljevic, 2011). Also, there is a growing body of knowledge supporting the role of neurotransmitter genetic variations which may influence clinical response to different psychopharmacologic agents (Zhang et al, 2010). Method Assessment started in 2010 when the twin patients were 16 years old and diagnosed with schizophrenia in accordance with the Kiddie- Sads-Present and Lifetime version (K-SADS-PL) semi-structured interview. Effectiveness of the therapy was assessed using clinical scales: Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression – Severity of Illness Scale (CGI-S), Clinical Global Impression – Improvement Scale (CGI-I), Children’s Global Assessment Scale (CGAS). Results Both twins showed improvement in positive, negative and cognitive symptoms and are now functioning normally and without symptoms. Their response to risperidone was similar, as well as their symptom improvement. Conclusion Genetic factors can be an important factor when predicting treatment efficiency of risperidone, as well as other antipsychotic agents.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA