Naslov
Lower Incidence of Hepatic Metastases of Colorectal Cancer in Patients with Chronic Liver Diseases : Meta-analysis

Autori
Augustin, Goran ; Bruketa, Tomislav ; Korolija-Marinić, Dragan ; Milošević, Milan

Izvornik
Hepato-gastroenterology (0172-6390) 60 (2013), 125; 1064-1069

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
colorectal carcinoma; liver metastasis; chronic liver injury; meta-analysis

Sažetak
The rarity of metastatic malignancy in injured liver has been noticed. This meta-analysis evaluates the difference in occurrence of metastatic colorectal cancer in healthy and chronically injured liver. Methodology: Literature search of occurrence of metastatic colorectal cancer in chronically injured liver opposed to healthy liver was conducted. Chronically injured/damaged liver included cirrhosis, steatosis or fatty liver and infection with Hepatitis virus B or C. Results: A total of 7 retrospective studies between 1992 and 2010 matched the selection criteria with total of 4049 patients. Results suggest significantly lower incidence of colorectal metastasis in chronically injured liver (Pooled odds ratio = 0.260 (95% CI = 0.18 to 0.38) ; χ² (test odds ratio differs from 1) = 45.90 (df = 1) ; p <0.0001). Conclusions: Patients with chronic liver injury have significantly lower occurrence of hepatic metastasis of primary colorectal cancer than the patients with healthy liver.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA