Pregled bibliografske jedinice broj: 635181
Esophageal metastases of hepatocellular carcinoma following liver transplantation
Esophageal metastases of hepatocellular carcinoma following liver transplantation // International journal of case reports and images, 1 (2010), 4; 7-11 doi:10.5348/ijcri-2010-12-10-CR-2 (međunarodna recenzija, prikaz, znanstveni)
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Naslov
Esophageal metastases of hepatocellular carcinoma following liver transplantation
Autori
Škurla, Bruno ; Mlinarić, Aleksandra ; Nadalin, Sergej ; Katičić, Miroslava ; Naumovski-Mihalić ; Slavica
Izvornik
International journal of case reports and images (0976-3198) 1
(2010), 4;
7-11
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni
Ključne riječi
Malignant diseases of the liver ; Alcoholic liver cirrhosis ; Hepatocellular carcinoma ; Orthotopic liver transplantation ; Esophageal metastases
Sažetak
Introduction: Distal metastases occur in 30 to 75% cases of advanced hepatocellular carcinoma and the most common sites are the lungs, bones, intraperitoneal organs and adrenal gland. The most frequent metastases, except those mentioned above, are in the regional lymph nodes. Metastases to the esophagus are very rare, being present in less than 0.4% of patients with hepatocellular carcinoma. Case Report: We present a case of a 56-year-old male patient who had been treated for alcoholic liver cirrhosis and hepatocellular carcinoma in cirrhotic liver, followed by orthotopic liver transplantation (OLT). Three months after OLT patient was admitted to the hospital due to anemia. The upper gastrointestinal endoscopy revealed two lesions in the lower part of the esophagus, of which the lesion at the cardia severely bleed. Sclerotherapy was the method of choice in order to stop bleeding which was followed by surgery after sclerotherapy failed. Biopsies of the esophageal lesions showed metastases of hepatocellular carcinoma, while multiple metastases in the lungs and the mediastinum had been diagnosed earlier. After the patient had recovered from surgery sorafenib was suggested as adjuvant therapy. The patient gave up on further treatment and eventually passed away. Conclusion: The presently available scanning methods in severely ill patients will not always detect extrahepatic metastases of the liver cancer, thus causing an inappropriate use of liver transplantation. OLT failure resulting in spreading of the hepatocellular carcinoma will make us redefine the criteria for liver transplantation.
Izvorni jezik
Engleski
