Naslov
Clinical, biochemical and hormonal characteristics of polycystic ovary syndrome in Croatian population.

Autori
Piljek, Amanda Nicole

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Medicinski fakultet

Mjesto
Zagreb

Datum
Podatak o recenziji nije dostupan

Godina
2012

Stranica
29

Mentor
Pavičić Baldani, Dinka

Ključne riječi
polycystic ovary syndrome; hirsutism; obesity

Sažetak
Polycystic ovary syndrome (PCOS) is a common endocrine condition affecting women of reproductive age. There are many typical signs and symptoms that allow for the diagnosis of PCOS, depending on the criteria used. Interestingly, ethnicity influences the extent of these signs and symptoms ; therefore, the frequency of symptoms varies between different countries and ethnic groups. The prevalence of PCOS in Croatia is unknown, and it’s clinical and biochemical characteristics have not yet been reported. During this study, we used the Rotterdam criteria to evaluate 365 Croatian women with PCOS, and compared them to 304 age matched controls to assess the clinical, biochemical and hormonal abnormalities that occur in PCOS patients. The mean age of PCOS patients at presentation was 26.1±5.9 years and of controls were 28.0±4.2 years. Women with PCOS has significantly higher body mass index (BMI) than the control group, although in both groups most patients had normal weight (76.2% vs. 87.8%). Menstrual cycle abnormalities were observed in 90.7% of PCOS patients, and ultrasonographic appearance of polycystic ovaries was reported in 97.3% of PCOS cases. Nearly 75% of patients with PCOS had hirsutism and 49.6% had acne. We recoreded significantly higher serum levels of luteinizing hormone (LH), total testosterone (TT), free testosterone (fT) and insulin, while the serum levels of sex hormone binding globuline (SHBG) and follicular stimulating hormone (FSH) were significantly lower than in the control group. Serum glucose values were not significantly different between the groups. In conclusion, chronic anovulation, hirsutism and ultrasound appearance of polycystic ovaries are the dominant features of PCOS in Croatian population. The majority of patiens with PCOS had normal body weight. The incidence of insulin resistance in this group of patients is less than the previously decribed frequency in other populations of patients with PCOS and normal weight.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA