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Pregled bibliografske jedinice broj: 633495

Antioxidant and Antihypertensive Activity of Extract from Thymus Serpyllum L. in Experimental Hypertension

Mihailović-Stanojević, Nevena; Belščak-Cvitanović, Ana; Grujić Milanović, Jelica; Ivanov, Milan; Jovović, Đurđica; Bugarski, Dijana; Miloradović, Zoran
Antioxidant and Antihypertensive Activity of Extract from Thymus Serpyllum L. in Experimental Hypertension // Plant foods for human nutrition, 68 (2013), 3; 235-240 doi:10.1007/s11130-013-0368-7 (međunarodna recenzija, članak, znanstveni)

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Naslov
Antioxidant and Antihypertensive Activity of Extract from Thymus Serpyllum L. in Experimental Hypertension

Autori
Mihailović-Stanojević, Nevena ; Belščak-Cvitanović, Ana ; Grujić Milanović, Jelica ; Ivanov, Milan ; Jovović, Đurđica ; Bugarski, Dijana ; Miloradović, Zoran

Izvornik
Plant foods for human nutrition (0921-9668) 68 (2013), 3; 235-240

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antioxidant; hypertension; Mediterranean diet; blood pressure; peripheral resistance; nitric oxide; spontaneously hypertensive rats; rosmarinic acid; wild thyme

Sažetak
The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential antihypertensive effect of aqueous extract obtained from Thymus serpyllum L. (wild thyme, TE), an aromatic herb from the Lamiaceae family (highly present in Mediterranean diet), in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats. Total phenol content of TE was 2008.33 ± 10.6 mg/L GAE, and rosmarinic and caffeic acids were predominant phenolic compounds. The ferric reducing/antioxidant power and antioxidant capacity analysis revealed strong antioxidative properties of TE. In vitro nitric oxide-scavenging activity of 1mg/ml TE was 63.43% with the IC50 value of 122.36µg/ml. Bolus injection of TE (100 mg/kg body weight i.v.) induced significant decrease of systolic and diastolic blood pressure and total peripheral resistance in SHR, without effects on these parameters in normotensive Wistar rats. Cardiac index remained unchanged after TE treatment in all experimental rats. Given dose of TE didn’t show significant nitric oxide-scavenging activity in vivo. Our results indicate that TE may protect against hypertension in experimental model of essential hypertension.

Izvorni jezik
Engleski

Znanstvena područja
Prehrambena tehnologija



POVEZANOST RADA

Projekti:
058-0000000-3470 - Stabilnost alkaloida i polifenola u proizvodima biljnog podrijetla (Komes, Draženka, MZOS ) ( CroRIS)
20008001

Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb

Profili:

Avatar Url Ana Belščak-Cvitanović (autor)

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Mihailović-Stanojević, Nevena; Belščak-Cvitanović, Ana; Grujić Milanović, Jelica; Ivanov, Milan; Jovović, Đurđica; Bugarski, Dijana; Miloradović, Zoran
Antioxidant and Antihypertensive Activity of Extract from Thymus Serpyllum L. in Experimental Hypertension // Plant foods for human nutrition, 68 (2013), 3; 235-240 doi:10.1007/s11130-013-0368-7 (međunarodna recenzija, članak, znanstveni)
Mihailović-Stanojević, N., Belščak-Cvitanović, A., Grujić Milanović, J., Ivanov, M., Jovović, Đ., Bugarski, D. & Miloradović, Z. (2013) Antioxidant and Antihypertensive Activity of Extract from Thymus Serpyllum L. in Experimental Hypertension. Plant foods for human nutrition, 68 (3), 235-240 doi:10.1007/s11130-013-0368-7.
@article{article, author = {Mihailovi\'{c}-Stanojevi\'{c}, Nevena and Bel\v{s}\v{c}ak-Cvitanovi\'{c}, Ana and Gruji\'{c} Milanovi\'{c}, Jelica and Ivanov, Milan and Jovovi\'{c}, \DJur\djica and Bugarski, Dijana and Miloradovi\'{c}, Zoran}, year = {2013}, pages = {235-240}, DOI = {10.1007/s11130-013-0368-7}, keywords = {antioxidant, hypertension, Mediterranean diet, blood pressure, peripheral resistance, nitric oxide, spontaneously hypertensive rats, rosmarinic acid, wild thyme}, journal = {Plant foods for human nutrition}, doi = {10.1007/s11130-013-0368-7}, volume = {68}, number = {3}, issn = {0921-9668}, title = {Antioxidant and Antihypertensive Activity of Extract from Thymus Serpyllum L. in Experimental Hypertension}, keyword = {antioxidant, hypertension, Mediterranean diet, blood pressure, peripheral resistance, nitric oxide, spontaneously hypertensive rats, rosmarinic acid, wild thyme} }
@article{article, author = {Mihailovi\'{c}-Stanojevi\'{c}, Nevena and Bel\v{s}\v{c}ak-Cvitanovi\'{c}, Ana and Gruji\'{c} Milanovi\'{c}, Jelica and Ivanov, Milan and Jovovi\'{c}, \DJur\djica and Bugarski, Dijana and Miloradovi\'{c}, Zoran}, year = {2013}, pages = {235-240}, DOI = {10.1007/s11130-013-0368-7}, keywords = {antioxidant, hypertension, Mediterranean diet, blood pressure, peripheral resistance, nitric oxide, spontaneously hypertensive rats, rosmarinic acid, wild thyme}, journal = {Plant foods for human nutrition}, doi = {10.1007/s11130-013-0368-7}, volume = {68}, number = {3}, issn = {0921-9668}, title = {Antioxidant and Antihypertensive Activity of Extract from Thymus Serpyllum L. in Experimental Hypertension}, keyword = {antioxidant, hypertension, Mediterranean diet, blood pressure, peripheral resistance, nitric oxide, spontaneously hypertensive rats, rosmarinic acid, wild thyme} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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