Naslov
SAMPUS or melanoma in situ in the scrotal area.

Autori
Perković, Manuela ; Ulamec, Monika ; Grubišić, Igor ; Tomas, Davor ; Vučić, Majda

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Acta Clinica Croatica 51(1) / / - Zagreb : Klinički bolnički centar Sestre milosrdnice, 2011, 181-181

Skup
22nd LJudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 03.06.2011. - 04.06.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
melanoma in situ

Sažetak
Superficial atypical melanocytic proliferations of uncertain significance (SAMPUS) is a descriptive term for a heterogeneous group of melanocytic tumors that exhibit some features indicative of possible malignancy, but in number or degree insufficient to justify a malignant diagnosis. Tumors involving the scrotum are rare and primary malignant melanoma is the rarest of these lesions. To our knowledge, only 17 cases have been described since 1949 in the English speaking area. We present a case of a 59-year-old male patient diagnosed with SAMPUS in 2009, after excision of a scrotal skin lesion. Two years later, he presented with a brown pigmented area near the postoperative scar, measuring 0.6 cm in diameter. Histology showed partially thinned epidermis on the surface. In the basal layers of the epidermis, continuous lentiginous proliferation of single atypical melanocytes with nest formation and pagetoid spread to the upper layers of the epidermis was found. The basal membrane was preserved and continuous. Among the epidermal melanocytic nests, two mitoses were found. In the dermis, there were band-like dense lymphocytic infiltrates and pigmentophages, but no melanocytes. The lesion was diagnosed as melanoma in situ. Although most histologic diagnoses are made with relative ease, there is a subset of cases in which diagnosis is difficult or even impossible. The SAMPUS category includes certain atypical junctional melanocytic proliferations and proliferations in both the epidermis and papillary dermis that are not accompanied by intradermal tumorigenic architecture or mitotic activity. The prognosis for cure of these lesions as for melanoma in situ is excellent, if they are completely excised.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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