Naslov
In-line and off-line characterization of entacapone crystallization

Autori
Jednačak, Tomislav ; Hodzic, Aden ; Scheibelhofer, Otto ; Marijan, Marijan ; Khinast, Johannes ; Novak, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga Sažetaka / Hadžiev, Andrea ; Blažeković, Zdenko - Osijek : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013, 92-92

ISBN
978-953-6894-50-5

Skup
XXIII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Osijek, Hrvatska, 21.04.2013. - 24.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
entacapone; in-line Raman spectroscopy; crystallization; polymorphism

Sažetak
Many drugs are small organic molecules which can exist in different polymorphic forms. Since the polymorphic form of a drug may have a considerable impact on its therapeutic efficacy, it is crucial to isolate the polymorph with desired properties. The standard monitoring procedures do not provide real-time information on the crystallization process. Hence, new methodologies based on timely measurements of process variables are required to improve the product’s efficacy and quality control. Here we report on using in-line Raman spectroscopy and statistical analysis for monitoring the crystallization of drug Entacapone. Entacapone, E- 2-cyano-N, N-diethyl-3-(3, 4-dihydroxy-5-nitrophenyl) propenamide is used clinically for the treatment of Parkinson’s disease. The analysis of in-line Raman spectra coupled with principal component analysis and indirect hard modelling allowed the estimation of crystallization temperatures and preliminary identification of polymorphs. In order to unambiguously identify each polymorph present, the obtained crystals were further evaluated off-line via small and wide angle scattering (SWAXS) methods.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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