Pregled bibliografske jedinice broj: 631226
Blood pressure, acid-base and blood gas status and indicators of oxidative stress in healthy male rats exposed to acute hyperbaric oxygenation
Blood pressure, acid-base and blood gas status and indicators of oxidative stress in healthy male rats exposed to acute hyperbaric oxygenation // Undersea & hyperbaric medicine, 40 (2013), 4; 319-328 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 631226 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Blood pressure, acid-base and blood gas status and indicators of oxidative stress in healthy male rats exposed to acute hyperbaric oxygenation
Autori
Drenjančević, Ines ; Kibel, Aleksandar ; Kibel, Dijana ; Šerić, Vatroslav ; Ćosić, Anita
Izvornik
Undersea & hyperbaric medicine (1066-2936) 40
(2013), 4;
319-328
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
hyperbaric oxygenation; blood pressure; acid-base status; oxidative stress
Sažetak
Different protocols of hyperbaric oxygenation (HBO2)are used for research purposes ; however, data on the changes in blood pressure, oxidative stress and acidbase and gas status induced by various oxygenation protocols are scarce and conflicting. The aim of this study was to examine the effects of an acute session of HBO2 [2 bar (200 kPa) for two hours] on arterial systolic and diastolic blood pressure, arterial blood gases and acid-base status, and oxidative stress in rats. Sprague-Dawley rats (12-15 wks) were examined prior to, immediately and 24 hours after a two-hour HBO2 exposure at 2 bars. The femoral artery was cannulated to determine blood pressure, and blood samples were collected to measure blood gases and acid-base status, Ferric reducing antioxidant power ability of plasma (FRAP) and thiobarbituric acid reactive substances (TBARS).Immediately after HBO2 systolic and diastolic blood pressure significantly decreased (from138±14/103±13 to 113±12/72±16 mmHg). However, these values were still inside the normal physiological range. pH decreased (from 7.34±0.05 to 7.28±0.05), pCO2 decreased (from 7.07±0.89 to 5.76±0.50 kPa), pO2 increased (from 12.48±0.88 to 13.68±2.4 kPa), plasma bicarbonate decreased (from 27.04±3.25 to 20.52±3.02 mmol/L). Exposure to HBO2 immediately increased TBARS levels (from 0.17 ±0.09 to 21.79± 1.05 microM/MDA), while FRAP levels were not significantly changed. Measurements on separate animals 24 hours after a single HBO2 exposure showed no differences in comparison to control animals, except for pO2, which was significantly lower (11.10±0.31 kPa). The results define values of important parameters, serving as a necessary basis for complex analysis of HBO2 effects in research on rat animal models.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
219-2160133-2034 - Djelovanje kisika na vaskularnu funkciju u zdravlju i bolesti (Drenjančević, Ines, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Osijek
Profili:
Anita Matić
(autor)
Vatroslav Šerić
(autor)
Ines Drenjančević
(autor)
Aleksandar Kibel
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE