Pregled bibliografske jedinice broj: 630351
Photodegradation of sulfonamides and their N4-acetylated metabolites in water by simulated sunlight irradiation: kinetics and identification of photoproducts
Photodegradation of sulfonamides and their N4-acetylated metabolites in water by simulated sunlight irradiation: kinetics and identification of photoproducts // Environmental science and pollution research, 20 (2013), 12; 8934-8946 doi:10.1007/s11356-013-1836-1 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 630351 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Photodegradation of sulfonamides and their N4-acetylated metabolites in water by simulated sunlight irradiation: kinetics and identification of photoproducts
Autori
Periša, Martina ; Babić, Sandra ; Škorić, Irena ; Frömel, Tobias ; Knepper, Thomas P.
Izvornik
Environmental science and pollution research (0944-1344) 20
(2013), 12;
8934-8946
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
photolysis ; pharmaceuticals ; sulfonamides ; metabolites ; degradation pathways ; aqueous system
Sažetak
Once released into the aquatic environment, pharmaceuticals may undergo different degradation processes. Photodegradation for example might be an important elimination process for light sensitive pharmaceuticals, such as antibiotics. In this study the fate of sulfonamides (sulfamethazine, sulfadiazine and sulfamethoxazole) and their N4-acetylated metabolites (N4-acetylsulfadiazine, N4- acetylsulfamethazine and N4- acetylsulfamethoxazole) under simulated sunlight irradiation was investigated. The irradiation resulted in total or almost total degradation (88% to 98%) for pharmaceuticals tested, except for sulfamethazine (52%) during 24 h of irradiation. The photoproducts of all investigated pharmaceuticals have been analyzed using high- performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry. Structure elucidation performed from photodegradation products of both, sulfonamides and their N4-acetylated metabolites, clearly showed two major formation pathways. These were cleavage of the sulfonamide bond as well as SO2 extrusion. In total, nine photoproducts were elucidated. Among these photoproducts the tautomers of desulfonated sulfadiazine, sulfamethazine and sulfamethoxazole were also present. Tautomers of sulfadiazine and sulfamethazine have been characterized here for the first time as well as some photoproducts of sulfadiazine, sulfametoxazole and their metabolites N4-acetylsulfadiazine and N4- acetylsulfametoxazole. The obtained results are an important piece in the complex puzzle for assessing the environmental fate of sulfonamides and their metabolites in the environment.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
MZOS-125-0982933-2926 - Heteropolicikli, strukturne osnove za bioaktivne spojeve. Sinteza i fotokemija (Škorić, Irena, MZOS ) ( CroRIS)
MZOS-125-1253008-1350 - Razvoj naprednih analitičkih metoda za određivanje farmaceutika u okolišu (Babić, Sandra, MZOS ) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- CA Search (Chemical Abstracts)
