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Pregled bibliografske jedinice broj: 628510

Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.

Boraska, Vesna; Day-Williams, A; Franklin, CS; Elliott, KS; Panoutsopoulou, K; Tachmazidou, I; Albrecht, E; Bandinelli, S; Beilin, LJ; Bochud, M et al.
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. // PLoSOne, 7 (2012), 3; e31369-e31369 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 628510 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.

Autori
Boraska, Vesna ; Day-Williams, A ; Franklin, CS ; Elliott, KS ; Panoutsopoulou, K ; Tachmazidou, I ; Albrecht, E ; Bandinelli, S ; Beilin, LJ ; Bochud, M ; Cadby, G ; Ernst, F ; Evans, DM ; Hayward, Caroline ; Hicks, AA ; Huffman, J ; Huth, C ; James, AL ; Klopp, N ; Kolcic, Ivana ; Kutalik, Z ; Lawlor, DA ; Musk, AW ; Pehlic, Marina ; Pennell, CE ; Perry, JR ; Peters, A ; Polasek, Ozren ; St Pourcain, B ; Ring, SM ; Salvi, E ; Schipf, S ; Staessen, JA ; Teumer, A ; Timpson, N ; Vitart, V ; Warrington, NM ; Yaghootkar, H ; Zemunik, Tatijana ; Zgaga, Lina ; An, P ; Anttila, V ; Borecki, IB ; Holmen, J ; Ntalla, I ; Palotie, A ; Pietiläinen, KH ; Wedenoja, J ; Winsvold, BS ; Dedoussis, GV ; Kaprio, J ; Province, MA ; Zwart, JA ; Burnier, M ; Campbell. H ; Cusi, D ; Smith, GD ; Frayling, TM ; Gieger, C ; Palmer, LJ ; Pramstaller, PP ; Rudan, Igor ; Völzke, H ; Wichmann, HE ; Wright, AF ; Zeggini, E

Izvornik
PLoSOne (1932-6203) 7 (2012), 3; E31369-e31369

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Brachial circumference; genetic variants; genome-wide association scan (GWAS) meta-analysis

Sažetak
Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22, 376 individuals (12, 031 women and 10, 345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p<0.05) in the age-adjusted strata for men and across both sexes. In this first GWAS meta-analysis for BC to date, we have not identified any genome-wide significant signals and do not observe robust association of previously established obesity loci with BC. Large-scale collaborations will be necessary to achieve higher power to detect loci underlying BC.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
HRZZ-PD-02.03/68 - Analiza i interpretacija cjelogenomskih studija povezanosti: primjena u projektu 10,001 Dalmatinac
216-1080315-0293 - Genetska epidemiologija šećerne bolesti tip 1 u populaciji Hrvatske (Zemunik, Tatijana, MZOS ) ( CroRIS)
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Tatijana Zemunik (autor)

Avatar Url Marina Pehlić (autor)

Avatar Url Vesna Boraska Perica (autor)

Avatar Url Lina Zgaga (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Ivana Kolčić (autor)

Citiraj ovu publikaciju:

Boraska, Vesna; Day-Williams, A; Franklin, CS; Elliott, KS; Panoutsopoulou, K; Tachmazidou, I; Albrecht, E; Bandinelli, S; Beilin, LJ; Bochud, M et al.
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. // PLoSOne, 7 (2012), 3; e31369-e31369 (međunarodna recenzija, članak, znanstveni)
Boraska, V., Day-Williams, A., Franklin, C., Elliott, K., Panoutsopoulou, K., Tachmazidou, I., Albrecht, E., Bandinelli, S., Beilin, L. & Bochud, M. (2012) Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.. PLoSOne, 7 (3), e31369-e31369.
@article{article, author = {Boraska, Vesna and Day-Williams, A and Franklin, CS and Elliott, KS and Panoutsopoulou, K and Tachmazidou, I and Albrecht, E and Bandinelli, S and Beilin, LJ and Bochud, M and Cadby, G and Ernst, F and Evans, DM and Hayward, Caroline and Hicks, AA and Huffman, J and Huth, C and James, AL and Klopp, N and Kolcic, Ivana and Kutalik, Z and Lawlor, DA and Musk, AW and Pehlic, Marina and Pennell, CE and Perry, JR and Peters, A and Polasek, Ozren and St Pourcain, B and Ring, SM and Salvi, E and Schipf, S and Staessen, JA and Teumer, A and Timpson, N and Vitart, V and Warrington, NM and Yaghootkar, H and Zemunik, Tatijana and Zgaga, Lina and An, P and Anttila, V and Borecki, IB and Holmen, J and Ntalla, I and Palotie, A and Pietil\"{a}inen, KH and Wedenoja, J and Winsvold, BS and Dedoussis, GV and Kaprio, J and Province, MA and Zwart, JA and Burnier, M and Cusi, D and Smith, GD and Frayling, TM and Gieger, C and Palmer, LJ and Pramstaller, PP and Rudan, Igor and V\"{o}lzke, H and Wichmann, HE and Wright, AF and Zeggini, E}, year = {2012}, pages = {e31369-e31369}, keywords = {Brachial circumference, genetic variants, genome-wide association scan (GWAS) meta-analysis}, journal = {PLoSOne}, volume = {7}, number = {3}, issn = {1932-6203}, title = {Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.}, keyword = {Brachial circumference, genetic variants, genome-wide association scan (GWAS) meta-analysis} }
@article{article, author = {Boraska, Vesna and Day-Williams, A and Franklin, CS and Elliott, KS and Panoutsopoulou, K and Tachmazidou, I and Albrecht, E and Bandinelli, S and Beilin, LJ and Bochud, M and Cadby, G and Ernst, F and Evans, DM and Hayward, Caroline and Hicks, AA and Huffman, J and Huth, C and James, AL and Klopp, N and Kolcic, Ivana and Kutalik, Z and Lawlor, DA and Musk, AW and Pehlic, Marina and Pennell, CE and Perry, JR and Peters, A and Polasek, Ozren and St Pourcain, B and Ring, SM and Salvi, E and Schipf, S and Staessen, JA and Teumer, A and Timpson, N and Vitart, V and Warrington, NM and Yaghootkar, H and Zemunik, Tatijana and Zgaga, Lina and An, P and Anttila, V and Borecki, IB and Holmen, J and Ntalla, I and Palotie, A and Pietil\"{a}inen, KH and Wedenoja, J and Winsvold, BS and Dedoussis, GV and Kaprio, J and Province, MA and Zwart, JA and Burnier, M and Cusi, D and Smith, GD and Frayling, TM and Gieger, C and Palmer, LJ and Pramstaller, PP and Rudan, Igor and V\"{o}lzke, H and Wichmann, HE and Wright, AF and Zeggini, E}, year = {2012}, pages = {e31369-e31369}, keywords = {Brachial circumference, genetic variants, genome-wide association scan (GWAS) meta-analysis}, journal = {PLoSOne}, volume = {7}, number = {3}, issn = {1932-6203}, title = {Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.}, keyword = {Brachial circumference, genetic variants, genome-wide association scan (GWAS) meta-analysis} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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