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Pregled bibliografske jedinice broj: 628424

Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90

Matokanović, Mirela; Barišić, Karmela; Filipović-Grčić, Jelena; Maysinger, Dušica
Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90 // European journal of pharmaceutical sciences, 50 (2013), 1; 149-158 doi:10.1016/j.ejps.2013.04.001 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 628424 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90

Autori
Matokanović, Mirela ; Barišić, Karmela ; Filipović-Grčić, Jelena ; Maysinger, Dušica

Izvornik
European journal of pharmaceutical sciences (0928-0987) 50 (2013), 1; 149-158

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cancer; Hsp70; Chitosan; siRNA nanocarriers; celastrol; tumor spheroids

Sažetak
Inducers of heat shock protein 70 (Hsp70) commonly promote cancer cell viability whereas inhibitors of Hsp90 reduce it. The anticancer agent celastrol, interferes with signal transduction pathways involving these heat shock proteins. The objective of this in vitro study was to silence inducible Hsp70 and to pro- mote celastrol-induced tumor cell death. Hsp70 siRNA loaded chitosan- TPP carriers were prepared by ionic gelation and characterized by photon correlation spectroscopy and asymmetric flow field-flow frac- tionation combined with dynamic light scattering. Viability of human leukemia and glioblastoma cells and Hsp70 silencing was determined following treatment with chitosan-TPP-Hsp70 siRNA particles. The results showed that silencing of Hsp70 by chitosan- TPP-Hsp70 siRNA treatment significantly reduced cell viability, and enhanced antiproliferative effects of celastrol in leukemia and glioblastoma cells. In glioblastoma spheroids, higher concentrations of celastrol and Hsp70 siRNA in chitosan-TPP nanocarriers were necessary to induce cell death.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA

Projekti:
006-0061117-1244 - Terapijski nanosustavi (Filipović-Grčić, Jelena, MZOS ) ( CroRIS)
006-0061117-1236 - Posttranskripcijsko utišavanje stresnih proteina pomoću siRNA nanoterapije (Barišić, Karmela, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Karmela Barišić (autor)

Avatar Url Mirela Matokanović (autor)

Avatar Url Jelena Filipović-Grčić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Matokanović, Mirela; Barišić, Karmela; Filipović-Grčić, Jelena; Maysinger, Dušica
Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90 // European journal of pharmaceutical sciences, 50 (2013), 1; 149-158 doi:10.1016/j.ejps.2013.04.001 (međunarodna recenzija, članak, znanstveni)
Matokanović, M., Barišić, K., Filipović-Grčić, J. & Maysinger, D. (2013) Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90. European journal of pharmaceutical sciences, 50 (1), 149-158 doi:10.1016/j.ejps.2013.04.001.
@article{article, author = {Matokanovi\'{c}, Mirela and Bari\v{s}i\'{c}, Karmela and Filipovi\'{c}-Gr\v{c}i\'{c}, Jelena and Maysinger, Du\v{s}ica}, year = {2013}, pages = {149-158}, DOI = {10.1016/j.ejps.2013.04.001}, keywords = {cancer, Hsp70, Chitosan, siRNA nanocarriers, celastrol, tumor spheroids}, journal = {European journal of pharmaceutical sciences}, doi = {10.1016/j.ejps.2013.04.001}, volume = {50}, number = {1}, issn = {0928-0987}, title = {Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90}, keyword = {cancer, Hsp70, Chitosan, siRNA nanocarriers, celastrol, tumor spheroids} }
@article{article, author = {Matokanovi\'{c}, Mirela and Bari\v{s}i\'{c}, Karmela and Filipovi\'{c}-Gr\v{c}i\'{c}, Jelena and Maysinger, Du\v{s}ica}, year = {2013}, pages = {149-158}, DOI = {10.1016/j.ejps.2013.04.001}, keywords = {cancer, Hsp70, Chitosan, siRNA nanocarriers, celastrol, tumor spheroids}, journal = {European journal of pharmaceutical sciences}, doi = {10.1016/j.ejps.2013.04.001}, volume = {50}, number = {1}, issn = {0928-0987}, title = {Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90}, keyword = {cancer, Hsp70, Chitosan, siRNA nanocarriers, celastrol, tumor spheroids} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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