Naslov
Procalcitonin in systemic and localized bacterial infection

Autori
Pavić, Marina ; Bronić, Ana ; Milevoj Kopčinović, Lara

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Biochemia medica vol.19(suppl.1) / Topić, Elizabeta ; Čvoriščec, Dubravka - Zagreb : Medicinska naklada, 2009, S173-S173

Skup
6. hrvatski kongres medicinskih biokemičara

Mjesto i datum
Supetar, Hrvatska, 30.09.2009. - 04.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
procalcitonin; systemic bacterial infection; localized bacterial infection

Sažetak
Background: Procalcitonin (PCT) has been proposed as a marker of infection in critically ill patients. The aim of the study was to compare the serum concentrations of PCT in patients with systemic and local bacterial infection. Materials and methods: According to clinical and microbiologic findings we divided 25 patients into two groups:group A-patients with systemic bacterial infection (positive blood cultures) and group B-local bacterial infection (other positive cultures). We determined in all patients C-reactive protein (CRP), PCT, leukocyte, non-segmented neutrophyle and platelet count. PCT was measured by enzyme-linked fluorescent immunoassay (mini Vidas) and CRP by immunoturbidimetric method (Dimension Xpand). Leukocyte and platelet count were determined on a XT-1800i (Sysmex). Differential blood count was determined by microscopic method in stained blood peripheral smear. Data were analyzed using the Medcalc software. The level of significance was set at P < 0.05. Results: The median concentrations of PCT were 1.32(range: 0.13-7.37) ng/mL in group A and 0.21 (range: 0.05-9.07) ng/mL in group B and differences between groups were statistically significant (P = 0.038). A significantly higher median platelet count (P = 0.012) was found in group B (327, range: 40-325 x 109/L) as compared to group A (140, range: 40-325 x 109/L). In contrast, median values of CRP, leukocyte and non-segment neutrophyle were not significantly different between groups (P = 0.071 ; P = 0.189 ; P = 0.239, respectively). Conclusion: According to obtained results, higher PCT concentrations combined with lower platelet counts in patients with systemic bacterial infection contribute to an improved stratification of patients at risk to develop major complications.

Izvorni jezik
Engleski

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