Naslov
Lipid profile in patients with chronic obstructive pulmonary disease

Autori
Milevoj Kopčinović, Lara ; Pancirov, Dolores ; Simić, Laur ; Čepelak, Ivana ; Žanić Grubišić, Tihana ; Rumora, Lada

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2nd European Joint Congress of EFLM and UEMS and 7th Congress of the Croatian Society for Medical Biochemistry and Laboratory medicine (CSMBLM) : Laboratory Medicine at the Clinical Interface : abstracts ; u: Biochemia Medica 22 (2012) (S) / - , 2012, A146-A147

Skup
2nd European Joint Congress of EFLM and UEMS (2 ; 2012) ; Congress of the Croatian Society for Medical Biochemistry and Laboratory medicine : Laboratory Medicine at the Clinical Interface (7 ; 2012)

Mjesto i datum
Dubrovnik, Hrvatska, 10.10.2012. - 13.10.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lipid profile; COPD

Sažetak
Chronic obstructive pulmonary disease (COPD) is a complex systemic disease associated with many comorbidities. Cardiovascular diseases (CVD) are the leading cause of death among patients with COPD. Our aim was to assess the lipid profile and the relationship between lipid and lung function parameters in COPD patients. The study included 38 healthy subjects (15 smokers, 10 ex-smokers, 13 non-smokers) and 103 COPD patients (31 smokers, 25 ex-smokers, 47 non-smokers). COPD patients were also subdivided according to disease severity (GOLD stages II-IV). FEV1 predicted and FEV1/FVC were determined by spirometry. Total cholesterol, triglycerides, HDL cholesterol, ApoA and ApoB were measured in sera of all participants, while LDL cholesterol and LDL/HDL and ApoB/ApoA ratios were calculated. Total cholesterol, triglycerides, LDL cholesterol and ApoA were lower, and ApoB/ApoA ratio was higher in patients with COPD (P=0.003, P<0.001, P=0.043, P<0.001, P=0.005, respectively). No differences were found in HDL cholesterol and ApoB concentrations and LDL/HDL ratio when comparing patients with healthy subjects. However, HDL was weakly negatively correlated with FEV1/FVC in the patient group (r= -0.27, P=0.006). In addition, neither disease severity nor smoking status influenced lipid parameters in COPD patients. Although COPD is associated with an increased risk of CVD, our results do not confirm a pro-atherogenic lipid pattern in these patients. However, further research including a larger number of participants is needed to clarify this dilemma.

Izvorni jezik
Engleski

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