Naslov
RNA SEQUENCING ANALYSIS OF HUMAN LIVER SINUSOIDAL ENDOTHELIAL CELLS REVEALS EVIDENCE FOR AN ANTI-INFLAMMATORY ROLE DURING HCV INFECTION

Autori
Papić, Neven ; Delker, Don ; Liu, Shuanghu, Rong, Xia ; Vince, Adriana ; Hagedorn, Curt

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of hepatology / - , 2013, S146-S147

Skup
The International Liver Congress 2013 ; The 48th annual meeting of the European Association for the Study of the Liver

Mjesto i datum
Amsterdam, Nizozemska, 24.04.2013. - 28.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
liver sinusodal endothelial cells; LSEC; HCV; inflammation; immune response; RNA-seq

Sažetak
This is the first comprehensive gene expression analysis of LSECs that provided insight into the broad portrait of genomic changes associated with the LSECs response to HCV and evidence that LSECs downregulate inflammation during HCV infection. Defining the mechanisms of HCV-LSEC interactions will facilitate the understanding of HCV induced liver disease and the role of LSECs in other inflammatory liver diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA