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Pregled bibliografske jedinice broj: 627069

New anticancer active phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding

Racane, Livio; Kraljević Pavelić, Sandra; Nhili, Raja; Depauw, Sabine; Constant, Charles-Paul; Ratkaj, Ivana; David-Cordonnier, Marie-Helene; Pavelić, Krešimir; Tralić-Kulenović, Vesna; Karminski-Zamola, Grace
New anticancer active phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding // XXIII. Hrvatski skup kemičara i kemijskih inženjera - Knjiga sažetaka / Hadžiev, A ; Blažeković, Z (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013. str. 144-144 (poster, nije recenziran, sažetak, znanstveni)

CROSBI ID: 627069 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
New anticancer active phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding

Autori
Racane, Livio ; Kraljević Pavelić, Sandra ; Nhili, Raja ; Depauw, Sabine ; Constant, Charles-Paul ; Ratkaj, Ivana ; David-Cordonnier, Marie-Helene ; Pavelić, Krešimir ; Tralić-Kulenović, Vesna ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIII. Hrvatski skup kemičara i kemijskih inženjera - Knjiga sažetaka / Hadžiev, A ; Blažeković, Z - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013, 144-144

ISBN
978-953-6894-50-5

Skup
XXIII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Osijek, Hrvatska, 21.04.2013. - 24.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Amidino-substituted benzothiazoles; Antitumor evaluation; DNA-binding

Sažetak
Novel amidino substituted derivatives of phenylene-bis-benzothiazoles were synthesized and their antiproliferative activity against several human cancer cell lines, as well as DNA-binding features were determined. All tested compounds showed antiproliferative effects on tumour cells in a time- and concentration- dependent manner. The strongest activity was observed for b. These effects were shown to be related to DNA-binding properties, topoisomerase I and II poisoning effects and apoptosis induction. The highest tested selectivity towards tumor cells was observed for compound d that showed no cytotoxic effects on normal fibroblasts.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Tekstilna tehnologija



POVEZANOST RADA

Projekti:
117-0000000-3283 - Istraživanje novih višenamjenskih bojila i optičkih bjelila (Racane, Livio, MZOS ) ( CroRIS)
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni (pametni) lijekovi (Hranjec, Marijana, MZOS ) ( CroRIS)
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Pavelić, Krešimir, MZOS ) ( CroRIS)

Ustanove:
Tekstilno-tehnološki fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Vesna Tralić-Kulenović (autor)

Avatar Url Livio Racane (autor)

Avatar Url Krešimir Pavelić (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Ivana Ratkaj (autor)

Avatar Url Grace Karminski-Zamola (autor)

Citiraj ovu publikaciju:

Racane, Livio; Kraljević Pavelić, Sandra; Nhili, Raja; Depauw, Sabine; Constant, Charles-Paul; Ratkaj, Ivana; David-Cordonnier, Marie-Helene; Pavelić, Krešimir; Tralić-Kulenović, Vesna; Karminski-Zamola, Grace
New anticancer active phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding // XXIII. Hrvatski skup kemičara i kemijskih inženjera - Knjiga sažetaka / Hadžiev, A ; Blažeković, Z (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013. str. 144-144 (poster, nije recenziran, sažetak, znanstveni)
Racane, L., Kraljević Pavelić, S., Nhili, R., Depauw, S., Constant, C., Ratkaj, I., David-Cordonnier, M., Pavelić, K., Tralić-Kulenović, V. & Karminski-Zamola, G. (2013) New anticancer active phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding. U: Hadžiev, A. & Blažeković, Z. (ur.)XXIII. Hrvatski skup kemičara i kemijskih inženjera - Knjiga sažetaka.
@article{article, author = {Racane, Livio and Kraljevi\'{c} Paveli\'{c}, Sandra and Nhili, Raja and Depauw, Sabine and Constant, Charles-Paul and Ratkaj, Ivana and David-Cordonnier, Marie-Helene and Paveli\'{c}, Kre\v{s}imir and Trali\'{c}-Kulenovi\'{c}, Vesna and Karminski-Zamola, Grace}, year = {2013}, pages = {144-144}, keywords = {Amidino-substituted benzothiazoles, Antitumor evaluation, DNA-binding}, isbn = {978-953-6894-50-5}, title = {New anticancer active phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding}, keyword = {Amidino-substituted benzothiazoles, Antitumor evaluation, DNA-binding}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI)}, publisherplace = {Osijek, Hrvatska} }
@article{article, author = {Racane, Livio and Kraljevi\'{c} Paveli\'{c}, Sandra and Nhili, Raja and Depauw, Sabine and Constant, Charles-Paul and Ratkaj, Ivana and David-Cordonnier, Marie-Helene and Paveli\'{c}, Kre\v{s}imir and Trali\'{c}-Kulenovi\'{c}, Vesna and Karminski-Zamola, Grace}, year = {2013}, pages = {144-144}, keywords = {Amidino-substituted benzothiazoles, Antitumor evaluation, DNA-binding}, isbn = {978-953-6894-50-5}, title = {New anticancer active phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding}, keyword = {Amidino-substituted benzothiazoles, Antitumor evaluation, DNA-binding}, publisher = {Hrvatsko dru\v{s}tvo kemijskih in\v{z}enjera i tehnologa (HDKI)}, publisherplace = {Osijek, Hrvatska} }

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