Pregled bibliografske jedinice broj: 624528
Molecular dynamics based studies on human DPP III revealed determinants for its broad substrate selectivity
Molecular dynamics based studies on human DPP III revealed determinants for its broad substrate selectivity // IRENE – 'In Silico Enzyme Sesign and Screening'
Trst, Italija, 2012. (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 624528 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Molecular dynamics based studies on human DPP III revealed determinants for its broad substrate selectivity
Autori
Tomić, Sanja ; Tomić, Antonija ; Gonzalez, Miguel
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
IRENE – 'In Silico Enzyme Sesign and Screening'
Mjesto i datum
Trst, Italija, 07.05.2012. - 09.05.2012
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Dipeptidylpeptidase III; molecular modelling
Sažetak
Dipeptidylpeptidase III (DPP III) is a zinc-exopeptidase which hydrolyses a number of biologically active peptides (e.g., endomorphin1, endomorphin2 and enkephalin), and also some synthetics substrates, e.g., ArgArg2naphthylamide (RRNA), by cleaving dipeptides sequentially from their N termini. Because of its physiological as well pathophysiological roles (contribution in the protein catabolism, regulatory role in the pain-modulatory system, and enhanced level of DPP III was found in several carcinoma). In order to find determinants for its broad specificity for peptides of varying lengths and composition, we performed a series of MD simulations based on studies on human DPP III and its complexes with different substrates.
Izvorni jezik
Engleski
Znanstvena područja
Fizika
POVEZANOST RADA
Projekti:
098-1191344-2860 - Proučavanje biomakromolekula računalnim metodama i razvoj novih algoritama (Tomić, Sanja, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
