Naslov
Polymorphisms in the Interleukin-1B And IL-1 Receptor Antagonist Genes in Predisposition to Hip and Knee Osteoarthritis in Croatian Population

Autori
Kaarvatn, M.H. ; Jotanovic, Zdravko ; Etokebe, G.E. ; Mihelic, Radovan ; Mulac-Jeričević, Biserka ; Tijanic, Tamara ; Balen, Sanja ; Sestan, Branko ; Dembic, Zlatko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Scandinavian Journal of Immunology / - , 2010

Skup
39th meeting of Scandinavian Society for Immunology jointly with the Baltic Immunological Society

Mjesto i datum
Talin, Estonija, 02.06.2010. - 05.06.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Genetic Predisposition to Disease; IL1; IL1RN; Knee; Osteoarthritis

Sažetak
Among the predisposing factors to either primary or secondary osteoarthritis (OA) is the complex genetic inheritance including differences in risks at different joints. The interleukin-1B (IL1B) and IL-1 receptor antagonist (IL1RN) genes were implicated in susceptibility to hip, knee and hand OA. Here we investigated genetic polymorphisms at IL1B SNP (1423C>T) and IL1RN VNTR in a case-control study with 497 patients (238 knee and 259 hip) who had undergone total joint replacements, and 505 healthy blood donors in Croatian population. Our results support some of the previous findings reported for the hip OA in European and American populations. The influence of these polymorphisms regarding predisposition to knee OA in Croatian (Caucasian) population will be summarized.

Izvorni jezik
Engleski

POVEZANOST RADA