Naslov
Calcipotriol - a vitamin D3 analogue (MC 903) in the treatment of psoriasis vulgaris

Autori
Čeović, Romana ; Lipozenčić, Jasna ; Pašić, Aida

Izvornik
Acta Dermatovenerologica Alpina, Pannonica et Adriatica (1318-4458) 7 (1998), 2; 67-77

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
vitamin D; calcipotriol; plaque psoriasis; review

Sažetak
Calcipotriol, a vitamin D3 analogue, is an effective and well tolerated topical therapy of mild and medium intensive plaque psoriasis. Calcipotriol reduces epidermal cell prolifetarion and enhances differentiation in lesional skin. Calcipotriol ointment, applied twice daily, may be more effective than betamethazone valerate and dithranol. In combination with other antipsoriatic treatments (UVB, PUVA, Cyclosporin), it is used in therapy of severe psoriasis. The most frequently occuring adverse events are lesional and perilesional skin irritations. There is no risk of hypercalcemia if calcipotriol is used in recommended doses not more than 100 g weekly. Calcipotriol ointment is today an effective and safe alternative therapy for psoriasis vulgaris in children. For the treatment of scalp psoriasis a calcipotriol solution can be used. In this article, the literature is reviewed and different calcipotriol therapeutic modalities are discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA