Naslov
The inflfluence of transforming growth factor beta-1 proven in autologous omental graft on the healing of critical size defects in rabbit radius
(The influence of transforming growth factor beta-1 proven in autologous omental graft on the healing of critical size defects in rabbit radius)

Autori
Smolec, Ozren ; Radišić, Berislav ; Zhongjie , Liu ; Fan, Kai ; Brkljača Bottegaro, Nika ; Pećin, Marko ; Jelčić, Danijela ; Kos, Josip

Izvornik
VETERINARSKI ARHIV (0372-5480) 83 (2013), 2; 189-199

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rabbit ; omentum ; fat tissue ; bone ; healing

Sažetak
Fracture healing is a complex physiological process. Multiple factors regulate this cascade of molecular reactions, affecting different sites in the osteoblast lineage, through various processes such as: migration, proliferation, chemotaxis, differentiation, inhibition, and extracellular protein synthesis. The omentum is a serous membrane made up of a lattice of blood vessels and fat. Basically, it is a highly vasculated organ with a rich source of angiogenic factors that promote the growth of blood vessels into whatever tissue it is placed close to. Recent studies have revealed that the omentum, apart from being a great source of various growth factors, also contains omnipotent stem cells that can differentiate into a variety of cell types. The study was carried out on 16 adult male New Zealand rabbits in the same condition. A large segmental defect was created in the radius of each animal in groups A and B. In group B the defect was fifi lled with a piece omental fat tissue. The animals were euthanized 56 days after the operation and the bones removed for histomorphometric analysis. Histomorphometric analysis was performed. The osteoblast interface (Ob.S/BS) proved to be the statistically signififi cant parameter (P = 0.005). An osteoblast interface was found in the treated group in contrast to the control. The surface of trabecula covered with the osteiod and osteoblast interface showed a high degree of positive linear correlation, in both the control and the treated group. Our study shows that the statistically signififi cant osteoblast interface leads to the conclusion that omental fat tissue has a certain inflfl uence on bone turnover, especially on the formation of the newly-created bone.

Izvorni jezik
Engleski

POVEZANOST RADA