Pregled bibliografske jedinice broj: 621909
Protumor effects of proinflammatory mediators in breast cancer
Protumor effects of proinflammatory mediators in breast cancer // Periodicum biologorum, 114 (2012), 4; 489-496 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 621909 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Protumor effects of proinflammatory mediators in breast cancer
Autori
Sirotković-Skerlev, Maja ; Kulić, Ana ; Bradić, Lada ; Čačev, Tamara
Izvornik
Periodicum biologorum (0031-5362) 114
(2012), 4;
489-496
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
breast cancer ; cytokines ; chemokines
Sažetak
Inflammation is defined as an enabling characteristic of malignant growth. Many proinflammatory mediators have protumor capabilities. In this review we focus on the protumor effect of cytokines and chemokines in breast cancer. We discuss the role of interleukin 1β, interleukin 6, tumor necrosis factor α, CCL2, CCL5, and CXCL12 and its receptor CXCR4 as typical mediators implicated in breast cancer progression. We also analyze the impact of transcription factor NF-κB. Proinflammatory mediators with protumor effects should be considered as therapeutic targets in breast cancer. It is challenging how to find optimal anti-cytokine and anti-chemokine regiments as a part of anticancer therapy.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( CroRIS)
108-1080058-0046 - KARCINOM DOJKE-MOLEKULARNE,GENETSKE I KLINIČKE KARAKTERISTIKE (Vrbanec, Damir, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
