Naslov
Monitoring of Helicobacter pylori eradication by quantitative ELISA Pyloriset EIA-G

Autori
Vukadinović, Marija Vesna ; Zubčić, Ana ; Antoljak, Nataša ; Topić, Elizabeta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Advances in Clinical Pathology 1 (1997), 2, suppl. 1 / Gonano, F. ; Lukač-Bajalo, J. ; Brguljan-Meško, P. ; Marc, J. - Udine : Eurostampa, 1997, 42-42

Skup
4th International Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Bled, Slovenija, 22.05.1997. - 24.05.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; gastritis; monitoring treatment; serology

Sažetak
Helicobacter pylori (HP) infection results in inflammation of the gastric mucosa, termed chronic superficial gastritis, developing peptic ulceration in some patients. Proper treatment includes eradication of the causative microorganism. The aim of this study was to monitor the efficacy of anti-HP treatment by noninvasive quantitative serologic methods. The concentration of specific anti-HP IgG was measured in serum of 86 patients with positive dyspeptic illness history before treatment, and two, four and six months after the treatment by ELISA Pyloriset EIA-G (Orion Diagnostica, Finland) with a cutoff titer of 300 mg/l. Results showed that the mean percentage of titer decrease was greatest two months after treatment (47%, p<0.001). Statistically significant decrease continued after 4 and 6 months, respectively (58% and 69% of titer before therapy, p<0.05). According to some other authors, it would be satisfying to monitor titer during 4 months to be sure that HP is eradicated. Unlike those studies, our results show that 11% of patients become seroconverted (patients who˘s titer declined ł40 % of the value measured before therapy) not earlier than after 6 months, so we recommend six months monitoring.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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