Naslov
In vitro biological screening in discovery of hits & leads

Autori
Jelić, Dubravko ; Brajša, Karmen ; Banjanac, Mihailo ; Spaventi, Radan ; Vesna Eraković Haber

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Medicinal Chemistry in Drug Discovery. Design, Synthesis and Screening

Urednik/ci
Jelić, Dubravko

Izdavač
Transworld Research Network

Grad
Lahti

Godina
2013

Raspon stranica
261-300

ISBN
978-81-7895-560-5

Ključne riječi
Drug discovery, in vitro screening, automatisation of assays

Sažetak
The field of biological screening has evolved considerably since traditional medicine and serendipitous findings became more closely associated with technological advances in basic sciences at the end of the 19th and the beginning of the 20th century. This association became even more pronounced during the early 1990’s, when the parallel and combinatorial chemistry, as well as high-throughput biological screening revolution began. The concept of using a “high-throughput” paradigm for both chemistry and biology during drug discovery has advanced considerably in the last two decades. This chapter addresses the value and different aspects of in vitro biological screening in drug discovery, from definition of targets, through basic biological screening concepts, readout types and screening technologies, to reverse pharmacology, ‘mode of action’ studies and the role of biomarkers in drug discovery.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA