Naslov
Endemic nephropathy is aristolochic acid nephropathy: a urological controversy resolved.

Autori
Dittrich, Damir ; Medverec, Zvonimir ; Jakovina, Krunoslav ; Jakovina, Tratinčica ; Tomić, Karla ; Stipanić, Žellimir ; Vuković Lela, Ivana ; Karanović, Sandra ; Grollman, Arthur P ; Jelaković, Bojan.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract Book / - , 2010, A7-A8

Skup
The 3rd World Congress on Controversies in Urology

Mjesto i datum
Atena, Grčka, 25.02.2010. - 28.02.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Endemic nephropathy; aristolochic acid

Sažetak
Endemic (Balkan) nephropathy (EN) is characterized by an insidious onset, slow progression to end stage renal disease and a strong association with upper urinary tract cancers (UUC). EN occurs only in rural villages, situated near tributaries of the Danube River ; epidemiologic studies reveal a familial aggregation, but not an inherited disease. Various environmental agents, including ocratoxin A have been proposed as putative causative factors of EN but strong evidence in support of these hypotheses in lacking. We have proposed that chronic dietary exposure to aristolochic acid (AA) is genetically susceptible individuals is uniquely responsible for EN and UUC. This hypothesis is supported by the unquivocal detection of 7-(deoxyadenosin_N6-yl) aristolactam DNA adducts in renal cortical and UUC tissues of patients with EN and/or UUC.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA